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Details on Person AKT1 phosphorylates NOTCH4

Class:IdReaction:9604328
_displayNameAKT1 phosphorylates NOTCH4
_doReleaseTRUE
_timestamp2018-05-09 14:10:41
authored[InstanceEdit:9604946] Orlic-Milacic, Marija, 2018-04-05
catalystActivity[CatalystActivity:450501] protein serine/threonine kinase activity of p-T308,S473-AKT1 [cytosol]
catalystActivityReference[CatalystActivityReference:9643421] protein serine/threonine kinase activity of p-T308,S473-AKT1 [cytosol] BRF1 protein turnover and mRNA decay activity are regulated by protein kinase B at the same phosphorylation sites
compartment[Compartment:70101] cytosol
created[InstanceEdit:9604333] Orlic-Milacic, Marija, 2018-04-02
edited[InstanceEdit:9608067] Orlic-Milacic, Marija, 2018-05-09
goBiologicalProcess[GO_BiologicalProcess:24614] negative regulation of Notch signaling pathway
input[EntityWithAccessionedSequence:157636] NICD4 [cytosol] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:9604316] AKT and 14-3-3 regulate Notch4 nuclear localization
modified[InstanceEdit:9604340] Orlic-Milacic, Marija, 2018-04-02
[InstanceEdit:9604341] Orlic-Milacic, Marija, 2018-04-02
[InstanceEdit:9608068] Orlic-Milacic, Marija, 2018-05-09
[InstanceEdit:9608071] Orlic-Milacic, Marija, 2018-05-09
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameAKT1 phosphorylates NOTCH4
output[EntityWithAccessionedSequence:9604329] p-4S-NICD4 [cytosol] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
releaseDate2018-06-12
reviewed[InstanceEdit:9608066] Haw, Robin, 2018-05-01
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9604336] R-HSA-9604328.3
summation[Summation:9604338] Recombinant human AKT1 phosphorylates recombinant human NICD...
(hasEvent)[Pathway:9604323] Negative regulation of NOTCH4 signaling [Homo sapiens]
(precedingEvent)[Reaction:9604387] p-4S-NICD4 binds YWHAZ [Homo sapiens]
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