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Details on Person Gamma-secretase cleaves NOTCH4

Class:IdReaction:9604294
_displayNameGamma-secretase cleaves NOTCH4
_doReleaseTRUE
_timestamp2018-05-09 14:42:48
authored[InstanceEdit:157021] Jassal, B, 2004-12-15 13:08:03
[InstanceEdit:9604946] Orlic-Milacic, Marija, 2018-04-05
catalystActivity[CatalystActivity:157355] aspartic-type endopeptidase activity of gamma-secretase complex [plasma membrane]
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:9604293] Orlic-Milacic, Marija, 2018-04-02
edited[InstanceEdit:9608067] Orlic-Milacic, Marija, 2018-05-09
goBiologicalProcess[GO_BiologicalProcess:937686] Notch receptor processing, ligand-dependent
inferredFrom
input[EntityWithAccessionedSequence:157641] NEXT4 [plasma membrane] [Homo sapiens]
modified[InstanceEdit:9604296] Orlic-Milacic, Marija, 2018-04-02
[InstanceEdit:9604305] Orlic-Milacic, Marija, 2018-04-02
[InstanceEdit:9604327] Orlic-Milacic, Marija, 2018-04-02
[InstanceEdit:9608068] Orlic-Milacic, Marija, 2018-05-09
[InstanceEdit:9608071] Orlic-Milacic, Marija, 2018-05-09
[InstanceEdit:9608080] Orlic-Milacic, Marija, 2018-05-09
[InstanceEdit:9608089] Orlic-Milacic, Marija, 2018-05-09
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameGamma-secretase cleaves NOTCH4
output[EntityWithAccessionedSequence:157636] NICD4 [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:157635] NOTCH4(1432-1466) [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate2005-06-12
reviewed[InstanceEdit:165114] Joutel, A, 2004-12-15
[InstanceEdit:9608066] Haw, Robin, 2018-05-01
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:9604946] Orlic-Milacic, Marija, 2018-04-05
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9604295] R-HSA-9604294.2
summation[Summation:178973] NEXT4 fragment of NOTCH4 is further cleaved at the S3 site b...
(hasEvent)[Pathway:9013700] NOTCH4 Activation and Transmission of Signal to the Nucleus [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9604308] NICD4 traffics to the nucleus [Homo sapiens]
[Reaction:9604328] AKT1 phosphorylates NOTCH4 [Homo sapiens]
[Reaction:9605414] NOTCH4 binds SMAD3 [Homo sapiens]
(replacementInstances)[_Deleted:9608082] Deletion of instance: 157648
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No pathways have been reviewed or authored by Gamma-secretase cleaves NOTCH4 (9604294)