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Details on Person ADAM10 cleaves NOTCH4

Class:IdBlackBoxEvent:9604264
_displayNameADAM10 cleaves NOTCH4
_doReleaseTRUE
_timestamp2022-09-13 18:03:33
authored[InstanceEdit:157021] Jassal, B, 2004-12-15 13:08:03
[InstanceEdit:9604946] Orlic-Milacic, Marija, 2018-04-05
catalystActivity[CatalystActivity:157208] metallopeptidase activity of ADAM10:Zn2+ [plasma membrane]
compartment[Compartment:876] plasma membrane
created[InstanceEdit:9604267] Orlic-Milacic, Marija, 2018-04-02
edited[InstanceEdit:9608067] Orlic-Milacic, Marija, 2018-05-09
goBiologicalProcess[GO_BiologicalProcess:937686] Notch receptor processing, ligand-dependent
inferredFrom
input[DefinedSet:9604269] DLL4:NOTCH4,JAG1:NOTCH4 [plasma membrane] [Homo sapiens]
isChimericFALSE
modified[InstanceEdit:9604285] Orlic-Milacic, Marija, 2018-04-02
[InstanceEdit:9604327] Orlic-Milacic, Marija, 2018-04-02
[InstanceEdit:9608068] Orlic-Milacic, Marija, 2018-05-09
[InstanceEdit:9608071] Orlic-Milacic, Marija, 2018-05-09
[InstanceEdit:9608080] Orlic-Milacic, Marija, 2018-05-09
[InstanceEdit:9816782] Orlic-Milacic, Marija, 2022-09-13
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameADAM10 cleaves NOTCH4
output[EntityWithAccessionedSequence:157641] NEXT4 [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate2005-06-12
reviewed[InstanceEdit:165114] Joutel, A, 2004-12-15
[InstanceEdit:9608066] Haw, Robin, 2018-05-01
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9604272] R-HSA-9604264.3
summation[Summation:9604271] Based on sequence similarity with other NOTCH family members...
(hasEvent)[Pathway:9013700] NOTCH4 Activation and Transmission of Signal to the Nucleus [Homo sapiens]
(precedingEvent)[Reaction:9604294] Gamma-secretase cleaves NOTCH4 [Homo sapiens]
(replacementInstances)[_Deleted:9608085] Deletion of instance: 157649
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No pathways have been reviewed or authored by ADAM10 cleaves NOTCH4 (9604264)