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Details on Person Class I Peroxisomal Membrane Proteins [cytosol]

Class:Id	DefinedSet:9603783
_displayName	Class I Peroxisomal Membrane Proteins [cytosol]
_timestamp	2019-01-28 04:51:48
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9603789] May, Bruce, 2018-03-24
hasMember	[EntityWithAccessionedSequence:382587] ABCD1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:1456456] ABCD2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:1456459] ABCD3 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9603777] ACBD5 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9603785] ALDH3A2-2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9603807] ATAD1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9033099] FIS1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9603796] GDAP1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9603782] PEX12 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9603795] PEX13 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9603806] PEX14 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9603790] PEX16 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9603779] PEX26 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9603794] PXMP2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9603776] PXMP4 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9603781] SLC25A17 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9625562] PEX11B [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9625570] PEX2 [cytosol] [Homo sapiens]
isOrdered	TRUE
literatureReference	[LiteratureReference:9603861] Assembly of Peroxisomal Membrane Proteins via the Direct Pex19p-Pex3p Pathway [LiteratureReference:9603864] Two different targeting signals direct human peroxisomal membrane protein 22 to peroxisomes [LiteratureReference:9603866] Multiple distinct targeting signals in integral peroxisomal membrane proteins [LiteratureReference:9603858] Two splice variants of human PEX19 exhibit distinct functions in peroxisomal assembly [LiteratureReference:9603845] Tail-anchored PEX26 targets peroxisomes via a PEX19-dependent and TRC40-independent class I pathway [LiteratureReference:9603852] The peroxisomal receptor Pex19p forms a helical mPTS recognition domain [LiteratureReference:9603840] Analysis of human Pex19p's domain structure by pentapeptide scanning mutagenesis [LiteratureReference:9033020] Targeting of hFis1 to peroxisomes is mediated by Pex19p [LiteratureReference:9603849] Function of the PEX19-binding site of human adrenoleukodystrophy protein as targeting motif in man and yeast. PMP targeting is evolutionarily conserved [LiteratureReference:9603844] The import competence of a peroxisomal membrane protein is determined by Pex19p before the docking step [LiteratureReference:9604094] PEX19 is a predominantly cytosolic chaperone and import receptor for class 1 peroxisomal membrane proteins [LiteratureReference:382605] PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis [LiteratureReference:9604061] Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences [LiteratureReference:9604115] In vitro transport of membrane proteins to peroxisomes by shuttling receptor Pex19p [LiteratureReference:9604068] Allosteric modulation of peroxisomal membrane protein recognition by farnesylation of the peroxisomal import receptor PEX19 [LiteratureReference:9624765] Predicting the targeting of tail-anchored proteins to subcellular compartments in mammalian cells [LiteratureReference:9625572] Targeting elements in the amino-terminal part direct the human 70-kDa peroxisomal integral membrane protein (PMP70) to peroxisomes [LiteratureReference:9625571] The peroxisomal membrane targeting elements of human peroxin 2 (PEX2) [LiteratureReference:9635336] Charcot-Marie-Tooth disease-associated mutants of GDAP1 dissociate its roles in peroxisomal and mitochondrial fission
modified	[InstanceEdit:9604131] May, Bruce, 2018-03-31 [InstanceEdit:9625563] May, Bruce, 2018-10-20 [InstanceEdit:9625576] May, Bruce, 2018-10-20 [InstanceEdit:9635355] May, Bruce, 2019-01-28
name	Class I Peroxisomal Membrane Proteins
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9603808] R-HSA-9603783.1
(hasComponent)	[Complex:9603787] PEX19:class I PMP [cytosol] [Homo sapiens]
(input)	[Reaction:9603804] PEX19 binds class I peroxisomal membrane proteins [Homo sapiens]
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No pathways have been reviewed or authored by Class I Peroxisomal Membrane Proteins [cytosol] (9603783)