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Details on Person Receptor protein tyrosine phosphatases PTPRO and PTPRS (PTPs...

Class:IdSummation:9603728
_displayNameReceptor protein tyrosine phosphatases PTPRO and PTPRS (PTPs...
_timestamp2018-03-27 00:40:46
created[InstanceEdit:9603727] Orlic-Milacic, Marija, 2018-03-23
literatureReference[LiteratureReference:6798242] Postsynaptic TrkC and presynaptic PTPσ function as a bidirectional excitatory synaptic organizing complex
[LiteratureReference:9603718] Structural basis for extracellular cis and trans RPTPσ signal competition in synaptogenesis
[LiteratureReference:9603741] Dimerization of tyrosine phosphatase PTPRO decreases its activity and ability to inactivate TrkC
[LiteratureReference:9603735] PTPsigma binds and dephosphorylates neurotrophin receptors and can suppress NGF-dependent neurite outgrowth from sensory neurons
[LiteratureReference:9603739] Expression of PTPRO during mouse development suggests involvement in axonogenesis and differentiation of NT-3 and NGF-dependent neurons
[LiteratureReference:9603742] Developmental co-expression and functional redundancy of tyrosine phosphatases with neurotrophin receptors in developing sensory neurons
modified[InstanceEdit:9603730] Orlic-Milacic, Marija, 2018-03-23
[InstanceEdit:9603749] Orlic-Milacic, Marija, 2018-03-23
[InstanceEdit:9603770] Orlic-Milacic, Marija, 2018-03-23
[InstanceEdit:9603900] Orlic-Milacic, Marija, 2018-03-27
textReceptor protein tyrosine phosphatases PTPRO and PTPRS (PTPsigma) are co-expressed with NTRK3 (TRKC) in a large portion of NTRK3 positive neurons. Recombinant PTPRO (Beltran et al. 2003, Hower et al. 2009, Tchetchelnitski et al. 2014) and PTPRS (Faux et al. 2007, Tchetchelnitski et al. 2014) are both able to bind NTRK3 and promote NTRK3 dephosphorylation, thus attenuating NTRK3 signaling. The precise mechanism has not been elucidated.

In addition to interaction between PTPRS and NTRK3 in-cis, extracellular domain of pre-synaptic PTPRS can bind in-trans to extracellular domain of post-synaptic NTRK3, contributing to synapse formation (Takahashi et al. 2011, Coles et al. 2014).

(summation)[BlackBoxEvent:9603719] Protein tyrosine phosphatases dephosphorylate NTRK3 [Homo sapiens]
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