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Details on Person In the absence of ligand, NTRK3 (TRKC) is cleaved by an unkn...
| Class:Id | Summation:9603536 |
|---|---|
| _displayName | In the absence of ligand, NTRK3 (TRKC) is cleaved by an unkn... |
| _timestamp | 2018-03-22 16:44:32 |
| created | [InstanceEdit:9603535] Orlic-Milacic, Marija, 2018-03-22 |
| literatureReference | [LiteratureReference:9603517] The TrkC receptor induces apoptosis when the dependence receptor notion meets the neurotrophin paradigm [LiteratureReference:9603514] The dependence receptor TrkC triggers mitochondria-dependent apoptosis upon Cobra-1 recruitment |
| modified | [InstanceEdit:9603546] Orlic-Milacic, Marija, 2018-03-22 |
| text | In the absence of ligand, NTRK3 (TRKC) is cleaved by an unknown caspase. CASP3 (caspase-3) cleaves NTRK3 in vitro, but CASP3 inhibitors do not prevent NTRK3 cleavage in live cells. CASP8 (caspase-8) is unable to cleave NTRK3 in vitro. A general caspase inhibitor prevents NTRK3 cleavage in live cells (Tauszig-Delamasure et al. 2007). |
| (summation) | [BlackBoxEvent:9603534] Unknown caspase cleaves NTRK3 [Homo sapiens] |
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No pathways have been reviewed or authored by In the absence of ligand, NTRK3 (TRKC) is cleaved by an unkn... (9603536)
