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Details on Person Activated NTRK3 stimulates PI3K activity

Class:Id	BlackBoxEvent:9603445
_displayName	Activated NTRK3 stimulates PI3K activity
_doRelease	TRUE
_timestamp	2018-08-15 18:09:18
authored	[InstanceEdit:9034018] Orlic-Milacic, Marija, 2018-01-02
catalystActivity	[CatalystActivity:9603444] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of NTF3:p-5Y-NTRK3 homodimer:PI3K [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9603442] Orlic-Milacic, Marija, 2018-03-21
edited	[InstanceEdit:9608101] Orlic-Milacic, Marija, 2018-05-09
inferredFrom	[BlackBoxEvent:9616944] Activated Ntrk3 stimulates PI3K activity [Mus musculus]
input	[SimpleEntity:179856] PI(4,5)P2 [plasma membrane] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
modified	[InstanceEdit:9603489] Orlic-Milacic, Marija, 2018-03-21 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9608099] Orlic-Milacic, Marija, 2018-05-09 [InstanceEdit:9608102] Orlic-Milacic, Marija, 2018-05-09 [InstanceEdit:9616943] Orlic-Milacic, Marija, 2018-08-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated NTRK3 stimulates PI3K activity
output	[SimpleEntity:179838] PI(3,4,5)P3 [plasma membrane] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:9603420] Activated NTRK3 promotes SRC autophosphorylation [Homo sapiens] [Reaction:9603419] Activated NTRK3 binds SRC [Homo sapiens] [Reaction:9603437] Activated NTRK3 binds IRS1 [Homo sapiens] [Reaction:9034714] NTRK3 dimers trans-autophosphorylate [Homo sapiens] [Reaction:9603420] Activated NTRK3 promotes SRC autophosphorylation [Homo sapiens] [Reaction:9603407] Activated NTRK3 binds PI3K [Homo sapiens] [Reaction:9034714] NTRK3 dimers trans-autophosphorylate [Homo sapiens]
regulatedBy	[PositiveRegulation:9603443] Positive regulation by 'NTF3:p-5Y-NTRK3 homodimer:MyrG-p-Y419-SRC,(NTF3:p-5Y-NTRK3 homodimer,NTF3:p-5Y-NTRK3 homodimer:MyrG-p-Y419-SRC) [plasma membrane]'
releaseDate	2018-06-12
reviewed	[InstanceEdit:9608098] Tsoulfas, Pantelis, 2018-05-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9603449] R-HSA-9603445.3
summation	[Summation:9603474] Activation of PI3K signaling downstream of NTRK3 (TRKC) is e...
(hasEvent)	[Pathway:9603381] Activated NTRK3 signals through PI3K [Homo sapiens]
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No pathways have been reviewed or authored by Activated NTRK3 stimulates PI3K activity (9603445)