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Details on Person PIP3 recruits PDK1 and AKT to the membrane

Class:Id	Reaction:9603279
_displayName	PIP3 recruits PDK1 and AKT to the membrane
_doRelease	TRUE
_timestamp	2018-04-30 09:14:18
authored	[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9603278] Varusai, Thawfeek, 2018-03-16
input	[CandidateSet:202088] AKT [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:202210] PDPK1 [cytosol] [Homo sapiens] [SimpleEntity:179838] PI(3,4,5)P3 [plasma membrane] [SimpleEntity:179838] PI(3,4,5)P3 [plasma membrane]
literatureReference	[LiteratureReference:199317] Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B
modified	[InstanceEdit:9603281] Varusai, Thawfeek, 2018-03-16 [InstanceEdit:9606780] Varusai, Thawfeek, 2018-04-25 [InstanceEdit:9607058] Varusai, Thawfeek, 2018-04-30 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PIP3 recruits PDK1 and AKT to the membrane
output	[Complex:198360] PDK1:AKT:PIP3 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:437162] PI3K alpha, beta, gamma convert PIP2 to PIP3 [Homo sapiens] [BlackBoxEvent:437118] GPVI stimulates PI3K beta, gamma [Homo sapiens] [Reaction:114542] RAC1,RAC2,RHOG activate PI3K [Homo sapiens] [Reaction:202365] PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 [Homo sapiens] [Reaction:202203] Recruitment of PI3K to plasma membrane [Homo sapiens] [Reaction:392300] G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 [Homo sapiens] [Reaction:392295] Gbeta:gamma recruits PI3K gamma [Homo sapiens] [BlackBoxEvent:198266] PI3K produces PIP3 and other phosphatidyl inositides [Homo sapiens] [Reaction:198315] Active IRS recruits PI3K to the plasma membrane and activates it [Homo sapiens] [Reaction:2045911] BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 [Homo sapiens] [Reaction:9606160] p-PIK3AP1 (p-BCAP) binds PIK3CD:PIK3R1 (PI3K delta) [Homo sapiens] [Reaction:2076220] CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 [Homo sapiens] [Reaction:9606887] p-CD19:VAV binds PI3K and GRB2 [Homo sapiens] [Reaction:389158] CD28 bound PI3K phosphorylates PIP2 to PIP3 [Homo sapiens] [Reaction:388832] PI3K binds CD28 [Homo sapiens]
releaseDate	2007-11-08
reviewed	[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9607059] R-HSA-9603279.2
summation	[Summation:198339] Phosphatidylinositides generated by PI3K recruit phosphatidy...
(hasEvent)	[Pathway:392451] G beta:gamma signalling through PI3Kgamma [Homo sapiens]
(replacementInstances)	[_Deleted:9607061] Deletion of instance: 198284
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