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Details on Person UniProt:P06876 Myb
Class:Id
ReferenceGeneProduct:95838
_chainChangeLog
chain:1-636 added on Sat February 7 2015
_displayName
UniProt:P06876 Myb
_timestamp
2024-02-26 04:39:14
chain
chain:1-636
checksum
0C6308E584726D01
comment
FUNCTION Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.SUBUNIT Binds to HIPK1 (By similarity). Interacts with HIPK2, MAF, MYBBP1A and NLK.INTERACTION Comprised of 3 domains; an N-terminal DNA-binding domain, a centrally located transcriptional activation domain and a C-terminal domain involved in transcriptional repression.DOMAIN C-terminal truncated mutants display increased transactivation.PTM SUMOylated by TRAF7; leading to MYB transcriptional activity inhibition.PTM Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.PTM Phosphorylated by NLK on multiple sites, which induces proteasomal degradation.PTM Phosphorylated by HIPK1. This phosphorylation reduces MYB transcription factor activity but not MYB protein levels (By similarity).
