Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person UniProt:Q9QYF3 Myo5a

Class:IdReferenceGeneProduct:95827
_chainChangeLoginitiator methionine:1 added on Fri February 6 2015;chain:2-1828 added on Fri February 6 2015;initiator methionine:1 for 95827 removed on Fri Nov 03 2023;initiator methionine: for 95827 added on Fri Nov 03 2023;initiator methionine: for 95827 removed on Fri Aug 15 2025;initiator methionine:1 for 95827 added on Fri Aug 15 2025
_displayNameUniProt:Q9QYF3 Myo5a
_timestamp2025-08-15 22:02:11
chaininitiator methionine:1
chain:2-1828
checksum5B3DE1C89AE36123
commentFUNCTION Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Can hydrolyze ATP in the presence of actin, which is essential for its function as a motor protein (By similarity). Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane (By similarity). May also be required for some polarization process involved in dendrite formation.CATALYTIC ACTIVITY ATP + H2O = ADP + phosphate + H(+)SUBUNIT May be a homodimer, which associates with multiple calmodulin or myosin light chains (By similarity). Interacts with RIPL2, the interaction is required for its role in dendrite formation (PubMed:19812310). Interacts with MLPH. Interacts with SYTL4 (By similarity). Interacts with MYRIP (By similarity). Interacts with RAB10; mediates the transport to the plasma membrane of SLC2A4/GLUT4 storage vesicles (By similarity). Interacts with FMR1; this interaction occurs in association with polyribosome (By similarity).DISEASE Defects in Myo5a are a cause of Dilute-opisthotonus (dop). Dop rats have diluted coat color and are occasionally associated with severe neurological disorders.SIMILARITY Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
descriptionrecommendedName: Unconventional myosin-Va alternativeName: Dilute myosin heavy chain, non-muscle
geneNameMyo5a
identifierQ9QYF3
isSequenceChangedFALSE
keywordAcetylation
Actin-binding
ATP-binding
Calmodulin-binding
Coiled coil
Motor protein
Myosin
Nucleotide-binding
Phosphoprotein
Protein transport
Reference proteome
Repeat
Transport
modified[InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10
[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
[InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12
[InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39
[InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18
[InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
[InstanceEdit:423310] Kanapin, AA
[InstanceEdit:435478] Kanapin, AA
[InstanceEdit:435871] Kanapin, AA
[InstanceEdit:447347] Kanapin, AA
[InstanceEdit:525883] Kanapin, AA
[InstanceEdit:613449] Kanapin, AA
[InstanceEdit:797602] Kanapin, AA
[InstanceEdit:937368] Yung, CK
[InstanceEdit:1042053] Yung, CK
[InstanceEdit:1220657] Yung, CK
[InstanceEdit:1300696] Yung, CK
[InstanceEdit:1301627] Yung, CK
[InstanceEdit:1551960] Weiser, JD
[InstanceEdit:1995863] Weiser, JD
[InstanceEdit:2132304] Weiser, JD
[InstanceEdit:2265580] Weiser, JD
[InstanceEdit:3132113] Weiser, JD
[InstanceEdit:4341137] Weiser, JD
[InstanceEdit:5263031] Weiser, JD
[InstanceEdit:5433710] Weiser, JD
[InstanceEdit:5618415] Weiser, JD
[InstanceEdit:5634237] Weiser, JD
[InstanceEdit:5673015] Weiser, JD
[InstanceEdit:9037114] Weiser, JD
[InstanceEdit:9637257] Weiser, JD
[InstanceEdit:9657908] Weiser, JD
[InstanceEdit:9676415] Weiser, JD
[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
[InstanceEdit:9948485] Weiser, Joel, 2025-05-21
[InstanceEdit:9963647] Weiser, Joel, 2025-08-15
nameMyo5a
referenceDatabase[ReferenceDatabase:2] UniProt
secondaryIdentifierMYO5A_RAT
sequenceLength1828
species[Species:48895] Rattus norvegicus
(referenceEntity)[EntityWithAccessionedSequence:8931593] Myo5a [cytosol] [Rattus norvegicus]
[Change default viewing format]
No pathways have been reviewed or authored by UniProt:Q9QYF3 Myo5a (95827)