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Details on Person UniProt:Q9WTI7 Myo1c
| Class:Id | ReferenceGeneProduct:95822 |
|---|---|
| _chainChangeLog | chain:1-1063 added on Fri February 6 2015 |
| _displayName | UniProt:Q9WTI7 Myo1c |
| _timestamp | 2026-02-20 21:41:45 |
| chain | chain:1-1063 |
| checksum | 494A31B8634A1AF9 |
| comment | FUNCTION Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which then are moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes.FUNCTION Involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation.SUBUNIT Interacts (via its IQ motifs) with CABP1 and CIB1; the interaction with CABP1 and CIB1 is calcium-dependent (PubMed:17994197). Interacts (via tail domain) with PLEKHB1 (via PH domain); the interaction is not affected by the presence or absence of calcium and CALM (PubMed:15976448). Interacts with POLR1A (PubMed:16514417). Interacts with POLR2A (PubMed:11030652, PubMed:16960872). Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21 (PubMed:16514417). Interacts (via its IQ motifs) with CALM; this precludes interaction with YWHAB (By similarity). Interacts with YWHAB; this precludes interaction with CALM (By similarity). Interacts with RPS6 (By similarity). Interacts with actin (By similarity). Interacts with LLPH (PubMed:26961175). Interacts with GLUT4 (PubMed:22918957). Interacts (via its IQ motifs) with SH3BGRL3; the interaction is dependent on calcium and takes place at membrane ruffles (By similarity).SUBCELLULAR LOCATION Colocalizes with CABP1 and CIB1 at cell margin, membrane ruffles and punctate regions on the cell membrane (PubMed:17994197). Colocalizes in adipocytes with GLUT4 at actin-based membranes (PubMed:12490950). Colocalizes with GLUT4 at insulin-induced ruffles at the cell membrane (PubMed:22918957). Localizes transiently at cell membrane to region known to be enriched in PIP2 (PubMed:16492791). Activation of phospholipase C results in its redistribution to the cytoplasm (PubMed:16492791). Colocalizes with RNA polymerase II (By similarity). Translocates to nuclear speckles upon exposure to inhibitors of RNA polymerase II transcription (By similarity).SUBCELLULAR LOCATION Colocalizes with RNA polymerase II in the nucleus (PubMed:11030652). Colocalizes with RNA polymerase I in nucleoli (PubMed:16514417). In the nucleolus, is localized predominantly in dense fibrillar component (DFC) and in granular component (GC) (By similarity). Accumulates strongly in DFC and GC during activation of transcription (By similarity). Colocalizes with transcription sites (PubMed:16514417). Colocalizes in the granular cortex at the periphery of the nucleolus with RPS6 (By similarity). Colocalizes in nucleoplasm with RPS6 and actin that are in contact with RNP particles (By similarity). Colocalizes with RPS6 at the nuclear pore level (By similarity).ALTERNATIVE PRODUCTS Isoform 3 is expressed in small intestine, pancreas, brain, kidney, skin, heart muscle, testis, striated muscle, spleen, liver and lung (at protein level). Expressed in brain, testis, adrenal glands, thymus, spleen, kidney, lung, heart, cochlea and vestibule. Expressed in sensory hair cells of the inner ear. Expressed in adipocytes.INDUCTION Up-regulated by serum.DOMAIN Binds directly to large unilamellar vesicles (LUVs) containing phosphatidylinositol 4,5-bisphosphate (PIP2) or inositol 1,4,5-trisphosphate (InsP3). The PIP2-binding site corresponds to the myosin tail domain (PH-like) present in its tail domain.PTM Isoform 2 contains a N-acetylmethionine at position 1.MISCELLANEOUS May be due to a frameshift.SIMILARITY Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.CAUTION Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1). |
| description | recommendedName: Unconventional myosin-Ic alternativeName: Myosin I beta shortName: MMI-beta shortName: MMIb |
| geneName | Myo1c |
| identifier | Q9WTI7 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Actin-binding Alternative splicing ATP-binding Calmodulin-binding Cell membrane Cell projection Cytoplasm Cytoplasmic vesicle Membrane Methylation Motor protein Myosin Nucleotide-binding Nucleus Phosphoprotein Reference proteome Repeat |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9819394] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | Myo1c |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | MYO1C_MOUSE O08571 O08834 Q3TBQ4 Q3U231 Q5ND46 Q5ND48 Q5ND49 Q9ERB6 Q9QW54 |
| sequenceLength | 1063 |
| species | [Species:48892] Mus musculus |
| (isoformParent) | [ReferenceIsoform:150708] UniProt:Q9WTI7-2 Myo1c [Mus musculus] [ReferenceIsoform:415824] UniProt:Q9WTI7-1 Myo1c [Mus musculus] [ReferenceIsoform:424962] UniProt:Q9WTI7-3 Myo1c [Mus musculus] [ReferenceIsoform:424963] UniProt:Q9WTI7-4 Myo1c [Mus musculus] |
| (referenceEntity) | [EntityWithAccessionedSequence:1449581] Myo1c [cytosol] [Mus musculus] [EntityWithAccessionedSequence:1449593] p-S736-Myo1c [cytosol] [Mus musculus] |
| (referenceSequence) | [ModifiedResidue:1449625] O-phospho-L-serine at 736 |
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No pathways have been reviewed or authored by UniProt:Q9WTI7 Myo1c (95822)
