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Details on Person UniProt:Q924K8 Mta3

Class:Id	ReferenceGeneProduct:95694
_chainChangeLog	chain:1-591 added on Fri February 6 2015
_displayName	UniProt:Q924K8 Mta3
_timestamp	2025-08-15 21:46:53
chain	chain:1-591
checksum	ABA5CB9E86FCE7E2
comment	FUNCTION Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6.SUBUNIT Component of the nucleosome remodeling and deacetylase (NuRD) repressor complex, composed of core proteins MTA1, MTA2, MTA3, RBBP4, RBBP7, HDAC1, HDAC2, MBD2, MBD3, and peripherally associated proteins CDK2AP1, CDK2AP2, GATAD2A, GATAD2B, CHD3, CHD4 and CHD5. The exact stoichiometry of the NuRD complex is unknown, and some subunits such as MBD2 and MBD3, GATAD2A and GATAD2B, and CHD3, CHD4 and CHD5 define mutually exclusive NuRD complexes. Interacts with BCL6. Interacts with NACC2 (By similarity). Interacts with PWWP2B (PubMed:34180153).SUBCELLULAR LOCATION Expressed in heart, brain, spleen, lung, liver and kidney.SIMILARITY Belongs to the metastasis-associated protein family.
description	recommendedName: Metastasis-associated protein MTA3
geneName	Mta3
identifier	Q924K8
isSequenceChanged	FALSE
keyword	3D-structure Alternative splicing Cytoplasm DNA-binding Metal-binding Nucleus Phosphoprotein Reference proteome Zinc Zinc-finger
modified	[InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9773244] Weiser, Joel [InstanceEdit:9834092] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
name	Mta3
referenceDatabase	[ReferenceDatabase:2] UniProt
secondaryIdentifier	MTA3_MOUSE Q8VC18
sequenceLength	591
species	[Species:48892] Mus musculus
(isoformParent)	[ReferenceIsoform:150634] UniProt:Q924K8-2 Mta3 [Mus musculus] [ReferenceIsoform:412424] UniProt:Q924K8-1 Mta3 [Mus musculus]
(referenceEntity)	[EntityWithAccessionedSequence:5096470] Mta3 [nucleoplasm] [Mus musculus]
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No pathways have been reviewed or authored by UniProt:Q924K8 Mta3 (95694)