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Details on Person UniProt:P02802 Mt1
Class:Id
ReferenceGeneProduct:95667
_chainChangeLog
chain:1-61 added on Fri February 6 2015
_displayName
UniProt:P02802 Mt1
_timestamp
2023-11-03 16:23:56
chain
chain:1-61
checksum
4B3754EC759C0ADB
comment
FUNCTION Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.DOMAIN Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.SIMILARITY Belongs to the metallothionein superfamily. Type 1 family.
