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Details on Person UniProt:P30307 CDC25C
| Class:Id | ReferenceGeneProduct:95494 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-473 added on Fri February 6 2015;initiator methionine:1 for 95494 removed on Fri Nov 03 2023;initiator methionine: for 95494 added on Fri Nov 03 2023;initiator methionine: for 95494 removed on Fri Aug 15 2025;initiator methionine:1 for 95494 added on Fri Aug 15 2025 |
| _displayName | UniProt:P30307 CDC25C |
| _timestamp | 2025-08-15 22:09:43 |
| chain | initiator methionine:1 chain:2-473 |
| checksum | 0658A1F1B9B8996A |
| comment | FUNCTION Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle (PubMed:8119945). When phosphorylated, highly effective in activating G2 cells into prophase (PubMed:8119945). Directly dephosphorylates CDK1 and activates its kinase activity (PubMed:8119945).CATALYTIC ACTIVITY O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphateSUBUNIT Interacts with MAPK14 and 14-3-3 proteins (PubMed:11333986). When phosphorylated on Ser-129 and/or Thr-130, interacts with PLK1 (PubMed:12595692). Interacts with MARK3/C-TAK1 (PubMed:12941695).SUBUNIT (Microbial infection) Interacts with HIV-1 Vpr; this interaction inactivates CDC25C phosphatase activity.INTERACTION Expressed predominantly in G2 phase.PTM Phosphorylated by CHEK1 and MAPK14 at Ser-216. This phosphorylation creates a binding site for 14-3-3 protein and inhibits the phosphatase. Phosphorylated by PLK4. Phosphorylated by PLK1, leading to activate the phosphatase activity. Phosphorylation by PLK3 at Ser-191 promotes nuclear translocation. Ser-198 is a minor phosphorylation site. Was initially reported to be phosphorylated by PLK3 at Ser-216 (PubMed:10557092). However, such phosphorylation by PLK3 was not confirmed by other groups. Phosphorylation at Thr-48, Thr-67, Ser-122, Thr-130, Ser-168 and Ser-214 occurs at G2 and G2-M transition and is probably catalyzed by CDK1. Ser-168 phosphorylation levels are lower than those at the other 5 CDK1 sites. Phosphorylation by CDK1 leads to increased activity.SIMILARITY Belongs to the MPI phosphatase family. |
| description | recommendedName: M-phase inducer phosphatase 3 ecNumber evidence="21"3.1.3.48 alternativeName: Dual specificity phosphatase Cdc25C |
| geneName | CDC25C |
| identifier | P30307 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Cell cycle Cell division Host-virus interaction Hydrolase Mitosis Nucleus Phosphoprotein Protein phosphatase Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | CDC25C |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:6798274] ENSEMBL:ENSG00000158402 CDC25C [Homo sapiens] |
| secondaryIdentifier | MPIP3_HUMAN D3DQB8 Q96PL3 Q9H168 Q9H2E8 Q9H2E9 Q9H2F1 |
| sequenceLength | 473 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:150493] UniProt:P30307-2 CDC25C [Homo sapiens] [ReferenceIsoform:150494] UniProt:P30307-5 CDC25C [Homo sapiens] [ReferenceIsoform:150495] UniProt:P30307-3 CDC25C [Homo sapiens] [ReferenceIsoform:150496] UniProt:P30307-4 CDC25C [Homo sapiens] [ReferenceIsoform:403599] UniProt:P30307-1 CDC25C [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:69741] CDC25C [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:75003] p-S216-CDC25C [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:156496] p-S216-CDC25C [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:156668] p-S198-CDC25C [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:157879] CDC25C [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:6802968] p-S191-CDC25C [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:8863654] p-T48,T67,S122,T130,S168,S214-CDC25C [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8863664] p-T48,T67,S122,T130,S168,S214-CDC25C [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:8981697] p-S198-CDC25C [cytosol] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:75806] O-phospho-L-serine at 216 [ModifiedResidue:156705] O-phospho-L-serine at 198 [ModifiedResidue:6802970] O-phospho-L-serine at 191 [ModifiedResidue:8863651] O-phospho-L-threonine at 67 [ModifiedResidue:8863652] O-phospho-L-serine at 168 [ModifiedResidue:8863655] O-phospho-L-serine at 122 [ModifiedResidue:8863656] O-phospho-L-threonine at 48 [ModifiedResidue:8863657] O-phospho-L-serine at 214 [ModifiedResidue:8863658] O-phospho-L-threonine at 130 |
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No pathways have been reviewed or authored by UniProt:P30307 CDC25C (95494)
