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Details on Person UniProt:P30305 CDC25B

Class:Id	ReferenceGeneProduct:95491
_chainChangeLog	chain:1-580 added on Fri February 6 2015
_displayName	UniProt:P30305 CDC25B
_timestamp	2025-02-21 19:19:54
chain	chain:1-580
checksum	EDE24B0E84AC1BE3
comment	FUNCTION Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner (PubMed:17332740). The three isoforms seem to have a different level of activity (PubMed:1836978).CATALYTIC ACTIVITY O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphateACTIVITY REGULATION Stimulated by B-type cyclins.SUBUNIT Interacts with MAPK14 and 14-3-3 proteins.INTERACTION Phosphorylated by BRSK1 in vitro. Phosphorylated by CHEK1, which inhibits the activity of this protein. Phosphorylation at Ser-353 by AURKA might locally participate in the control of the onset of mitosis. Phosphorylation by MELK at Ser-169 promotes localization to the centrosome and the spindle poles during mitosis. Phosphorylation at Ser-323 and Ser-375 by MAPK14 is required for binding to 14-3-3 proteins.SIMILARITY Belongs to the MPI phosphatase family.
description	recommendedName: M-phase inducer phosphatase 2 ecNumber evidence="19"3.1.3.48 alternativeName: Dual specificity phosphatase Cdc25B
geneName	CDC25B CDC25HU2
identifier	P30305
isSequenceChanged	FALSE
keyword	3D-structure Alternative splicing Cell cycle Cell division Cytoplasm Cytoskeleton Hydrolase Mitosis Phosphoprotein Protein phosphatase Proteomics identification Reference proteome
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name	CDC25B
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8988508] ENSEMBL:ENSG00000101224 CDC25B [Homo sapiens]
secondaryIdentifier	MPIP2_HUMAN D3DVY1 D3DVY2 D3DVY3 D3DVY4 O43551 Q13971 Q5JX77 Q6RSS1 Q9BRA6
sequenceLength	580
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:150491] UniProt:P30305-2 CDC25B [Homo sapiens] [ReferenceIsoform:150492] UniProt:P30305-3 CDC25B [Homo sapiens] [ReferenceIsoform:237782] UniProt:P30305-4 CDC25B [Homo sapiens] [ReferenceIsoform:403598] UniProt:P30305-1 CDC25B [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:69734] CDC25B [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:157412] CDC25B [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8863644] p-S50,T69,S160,S321,S470-CDC25B [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9929936] p-S-CDC25B [nucleoplasm] [Homo sapiens]
(referenceSequence)	[ModifiedResidue:8863642] O-phospho-L-threonine at 69 [ModifiedResidue:8863643] O-phospho-L-serine at 50 [ModifiedResidue:8863646] O-phospho-L-serine at 321 [ModifiedResidue:8863647] O-phospho-L-serine at 470 [ModifiedResidue:8863649] O-phospho-L-serine at 160 [ModifiedResidue:9929943] O-phospho-L-serine at unknown position
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No pathways have been reviewed or authored by UniProt:P30305 CDC25B (95491)