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Details on Person UniProt:Q9BUB5 MKNK1

Class:Id	ReferenceGeneProduct:95412
_chainChangeLog	chain:1-465 added on Fri February 6 2015
_displayName	UniProt:Q9BUB5 MKNK1
_timestamp	2025-02-21 18:58:51
chain	chain:1-465
checksum	CAE225C35DCB2B43
comment	FUNCTION May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)COFACTOR Phosphorylated and activated by the p38 kinases and kinases in the Erk pathway.SUBUNIT Interacts with the C-terminal regions of EIF4G1 and EIF4G2. Also binds to dephosphorylated ERK1 and ERK2, and to the p38 kinases.INTERACTION Ubiquitous.PTM Dual phosphorylation of Thr-250 and Thr-255 activates the kinase. Phosphorylation of Thr-385 activates the kinase. MAPK3/ERK1 is one of the kinases which activate MKNK1/MNK1. Phosphorylation by PAK2 leads to a reduced phosphorylation of EIF4G1.SIMILARITY Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
description	recommendedName: MAP kinase-interacting serine/threonine-protein kinase 1 ecNumber evidence="4 8"2.7.11.1 alternativeName: MAP kinase signal-integrating kinase 1 shortName: MAPK signal-integrating kinase 1 shortName: Mnk1
geneName	MKNK1 MNK1
identifier	Q9BUB5
isSequenceChanged	FALSE
keyword	3D-structure Alternative splicing ATP-binding Cytoplasm Kinase Magnesium Metal-binding Nucleotide-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Serine/threonine-protein kinase Transferase Translation regulation
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name	MKNK1
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:9000696] ENSEMBL:ENSG00000079277 MKNK1 [Homo sapiens]
secondaryIdentifier	MKNK1_HUMAN D3DQ20 D3DQ21 O00312 Q5TC06 Q5TC07 Q6V0N6
sequenceLength	465
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:150452] UniProt:Q9BUB5-2 MKNK1 [Homo sapiens] [ReferenceIsoform:237467] UniProt:Q9BUB5-3 MKNK1 [Homo sapiens] [ReferenceIsoform:413416] UniProt:Q9BUB5-1 MKNK1 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:163175] p-T-MKNK1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:163179] MKNK1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:211664] p-S27-MKNK1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:211671] p-T22-MKNK1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:947860] p-T250,T255,T385,S437-MKNK1 [cytosol] [Homo sapiens]
(referenceSequence)	[ModifiedResidue:163177] O-phospho-L-threonine at unknown position [ModifiedResidue:211665] O-phospho-L-serine at 27 [ModifiedResidue:211672] O-phospho-L-threonine at 22 [ModifiedResidue:947827] O-phospho-L-serine at 437 [ModifiedResidue:947828] O-phospho-L-threonine at 250 [ModifiedResidue:947839] O-phospho-L-threonine at 255 [ModifiedResidue:947849] O-phospho-L-threonine at 385
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No pathways have been reviewed or authored by UniProt:Q9BUB5 MKNK1 (95412)