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Details on Person UniProt:O09008 Mfng
| Class:Id | ReferenceGeneProduct:95161 |
|---|---|
| _chainChangeLog | chain:1-321 added on Fri February 6 2015 |
| _displayName | UniProt:O09008 Mfng |
| _timestamp | 2025-02-21 18:38:48 |
| chain | chain:1-321 |
| checksum | 76EBCEC2314C50CD |
| comment | FUNCTION Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules (PubMed:10935626). Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1 (PubMed:10935626, PubMed:28089369).CATALYTIC ACTIVITY 3-O-(alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP + H(+)CATALYTIC ACTIVITY 3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP + H(+)COFACTOR Has some activity with cobalt, magnesium and calcium, but not zinc.BIOPHYSICOCHEMICAL PROPERTIES Optimum pH is 5.SUBCELLULAR LOCATION Belongs to the glycosyltransferase 31 family.ONLINE INFORMATION manic fringe homolog (mfng) |
| description | recommendedName: fullName evidence="7"Beta-1,3-N-acetylglucosaminyltransferase manic fringe ecNumber evidence="3 4"2.4.1.222 alternativeName: O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase |
| geneName | Mfng |
| identifier | O09008 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Developmental protein Disulfide bond Glycoprotein Glycosyltransferase Golgi apparatus Manganese Membrane Metal-binding Reference proteome Signal-anchor Transferase Transmembrane Transmembrane helix |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9027688] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9796772] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | Mfng |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | MFNG_MOUSE |
| sequenceLength | 321 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:2023148] Mfng [Golgi membrane] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:O09008 Mfng (95161)
