Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:P33991 MCM4
| Class:Id | ReferenceGeneProduct:94950 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-863 added on Fri February 6 2015;initiator methionine:1 for 94950 removed on Fri Nov 03 2023;initiator methionine: for 94950 added on Fri Nov 03 2023;initiator methionine: for 94950 removed on Fri Aug 15 2025;initiator methionine:1 for 94950 added on Fri Aug 15 2025 |
| _displayName | UniProt:P33991 MCM4 |
| _timestamp | 2025-08-15 21:54:21 |
| chain | initiator methionine:1 chain:2-863 |
| checksum | 96D9CA2A7D88D015 |
| comment | FUNCTION Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:25661590, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:16899510, PubMed:25661590, PubMed:32453425, PubMed:9305914).CATALYTIC ACTIVITY ATP + H2O = ADP + phosphate + H(+)SUBUNIT Component of the MCM2-7 complex (PubMed:16899510, PubMed:9305914). The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6-MCM4-MCM7-MCM3-MCM5 (PubMed:16899510, PubMed:32453425, PubMed:9305914). Component of the CMG helicase complex, a hexameric ring of related MCM2-7 subunits stabilized by CDC45 and the tetrameric GINS complex (PubMed:32453425, PubMed:34694004, PubMed:34700328). Interacts with MCMBP (PubMed:17296731).INTERACTION Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses.PTM Sumoylated; SUMO2 modified in response to stress caused by inhibition of proteasome activity (in vitro).DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. Specifically a MCM467 subcomplex is shown to have in vitro helicase activity which is inhibited by the MCM2 subunit. The MCM2-7 hexamer is the proposed physiological active complex.SIMILARITY Belongs to the MCM family. |
| description | recommendedName: DNA replication licensing factor MCM4 ecNumber evidence="1"3.6.4.12 alternativeName: CDC21 homolog alternativeName: P1-CDC21 |
| geneName | MCM4 CDC21 |
| identifier | P33991 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation ATP-binding Cell cycle Chromosome DNA replication DNA-binding Helicase Hydrolase Isopeptide bond Nucleotide-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | MCM4 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9003645] ENSEMBL:ENSG00000104738 MCM4 [Homo sapiens] |
| secondaryIdentifier | MCM4_HUMAN Q8NEH1 Q99658 |
| sequenceLength | 863 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:68549] MCM4 [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P33991 MCM4 (94950)
