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Details on Person RAS85D:GTP complex is hydrolysed by NF1

Class:IdReaction:947780
_displayNameRAS85D:GTP complex is hydrolysed by NF1
_doReleaseFALSE
_timestamp2017-06-27 17:37:51
authored[InstanceEdit:947710] Williams, MG, 2010-09-09
catalystActivity[CatalystActivity:947803] GTPase activator activity of RAS85D:GTP:NF1 [plasma membrane]
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:947774] Williams, MG, 2010-09-13
figure[Figure:947966] /figures/DrosRasRafERKA15.jpg
input[Complex:947775] RAS85D:GTP:NF1 [plasma membrane] [Drosophila melanogaster]
isChimericFALSE
literatureReference[LiteratureReference:947793] Rescue of a Drosophila NF1 mutant phenotype by protein kinase A
[LiteratureReference:947789] A circadian output in Drosophila mediated by neurofibromatosis-1 and Ras/MAPK
[LiteratureReference:947795] Reduced growth of Drosophila neurofibromatosis 1 mutants reflects a non-cell-autonomous requirement for GTPase-Activating Protein activity in larval neurons
[LiteratureReference:947794] Kinetics of interaction between normal and proline 12 Ras and the GTPase-activating proteins, p120-GAP and neurofibromin. The significance of the intrinsic GTPase rate in determining the transforming ability of ras
[LiteratureReference:947764] Individual rate constants for the interaction of Ras proteins with GTPase-activating proteins determined by fluorescence spectroscopy
[LiteratureReference:947796] The mechanism of Ras GTPase activation by neurofibromin
modified[InstanceEdit:947989] Williams, MG, 2010-09-14
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:8879177] Wu, G, 2016-07-15
[InstanceEdit:9010639] D'Eustachio, Peter, 2017-06-27
nameRAS85D:GTP complex is hydrolysed by NF1
output[Complex:947773] RAS85D:GDP:NF1 [plasma membrane] [Drosophila melanogaster]
[SimpleEntity:29372] Pi [cytosol]
precedingEvent
species[Species:56210] Drosophila melanogaster
stableIdentifier[StableIdentifier:8890828] R-DME-947780.1
summation[Summation:947762] The Ras GTPase activating protein Neurofibromin 1 (NF1) hydr...
(hasEvent)[Pathway:508419] Ras GTPase cycle [Drosophila melanogaster]
(precedingEvent)[Reaction:947777] NF1 dissociates from RAS85D:GDP complex [Drosophila melanogaster]
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