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Details on Person UniProt:Q92918 MAP4K1
| Class:Id | ReferenceGeneProduct:94763 |
|---|---|
| _chainChangeLog | chain:1-833 added on Fri February 6 2015 |
| _displayName | UniProt:Q92918 MAP4K1 |
| _timestamp | 2025-02-21 19:29:28 |
| chain | chain:1-833 |
| checksum | 3C98CF01BE42E151 |
| comment | FUNCTION Serine/threonine-protein kinase, which plays a role in the response to environmental stress (PubMed:24362026). Appears to act upstream of the JUN N-terminal pathway (PubMed:8824585). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). May play a role in hematopoietic lineage decisions and growth regulation (PubMed:24362026, PubMed:8824585). Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity).CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)COFACTOR Interacts with MAP3K1 (PubMed:8824585). Interacts with FBXW8 (PubMed:24362026). Interacts with CLNK (via its SH2 domain) (By similarity).INTERACTION Expressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Also expressed at very low levels in lung, kidney, mammary glands and small intestine.PTM Autophosphorylates: phosphorylation promotes ubiquitination by the Cul7-RING(FBXW8) ubiquitin-protein ligase complex, leading to its degradation by the proteasome.PTM Tyrosine-phosphorylated after activation of hemopoietic cells.PTM Ubiquitinated by the Cul7-RING(FBXW8) ubiquitin-protein ligase complex following autophosphorylation, leading to its degradation by the proteasome.SIMILARITY Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. |
| description | recommendedName: Mitogen-activated protein kinase kinase kinase kinase 1 ecNumber evidence="8"2.7.11.1 alternativeName: Hematopoietic progenitor kinase alternativeName: MAPK/ERK kinase kinase kinase 1 shortName: MEK kinase kinase 1 shortName: MEKKK 1 |
| geneName | MAP4K1 HPK1 |
| identifier | Q92918 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing ATP-binding Kinase Nucleotide-binding Phosphoprotein Proteomics identification Reference proteome Serine/threonine-protein kinase Transferase Ubl conjugation |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8987656] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | MAP4K1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8997809] ENSEMBL:ENSG00000104814 MAP4K1 [Homo sapiens] |
| secondaryIdentifier | M4K1_HUMAN |
| sequenceLength | 833 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8977477] UniProt:Q92918-1 MAP4K1 [Homo sapiens] [ReferenceIsoform:8977478] UniProt:Q92918-2 MAP4K1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:201588] MAP4K1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:517900] MAP4K1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:517901] MAP4K1 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q92918 MAP4K1 (94763)
