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Details on Person UniProt:P97432 Nbr1
| Class:Id | ReferenceGeneProduct:94716 |
|---|---|
| _chainChangeLog | chain:1-988 added on Fri February 6 2015 |
| _displayName | UniProt:P97432 Nbr1 |
| _timestamp | 2026-02-20 22:46:15 |
| chain | chain:1-988 |
| checksum | E5BB4B281FE33CE0 |
| comment | FUNCTION Ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis (PubMed:31916398, PubMed:34374750). Possesses a double function during the selective autophagy by acting as a shuttle bringing ubiquitinated proteins to autophagosomes and also by participating in the formation of protein aggregates. Plays a role in the regulation of the innate immune response by modulating type I interferon production and targeting ubiquitinated IRF3 for autophagic degradation (By similarity). In response to oxidative stress, promotes an increase in SQSTM1 levels, phosphorylation, and body formation by preventing its autophagic degradation (PubMed:31916398). In turn, activates the KEAP1-NRF2/NFE2L2 antioxidant pathway (PubMed:31916398). Also plays non-autophagy role by mediating the shuttle of IL-12 to late endosome for subsequent secretion (PubMed:34374750).SUBUNIT Homooligomer and heterooligomer. Interacts with TRIM55 (By similarity). Interacts with titin/TTN (By similarity). Interacts with RNF29, USP8, MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2. Binds to ubiquitin and ubiquitinated proteins. Interacts with SQSTM1. Interacts with TAX1BP1. Interacts with IRF3; this interaction mediates autophagic degradation of IRF3 (By similarity). Interacts with IL12A and IL12B (PubMed:34374750). Interacts with SRBD1; this interaction clears SRBD1 through the autophagic-lysosomal pathway (By similarity).INTERACTION In cardiac muscles localizes to the sarcomeric M line (By similarity). Is targeted to lysosomes for degradation (By similarity).TISSUE SPECIFICITY Expressed in brain.INDUCTION In response to oxidative stress.DOMAIN The PB1 domain mediates interaction with SQSTM1.PTM Phosphorylated by GSK3A; this phosphorylation inhibits NBR1 involvement in the formation of ubiquitinated protein aggregates.DISRUPTION PHENOTYPE NBR1-conditional knockout mice are not affected concerning general autophagy. However, the deletion results in a slight but significant reduction on the number and size of SQSTM1 liquid droplets. |
| description | recommendedName: Next to BRCA1 gene 1 protein alternativeName: Membrane component chromosome 17 surface marker 2 homolog alternativeName: Neighbor of BRCA1 gene 1 protein |
| geneName | Nbr1 M17s2 |
| identifier | P97432 |
| isSequenceChanged | FALSE |
| keyword | Cytoplasm Cytoplasmic vesicle Lysosome Metal-binding Phosphoprotein Reference proteome Ubl conjugation Zinc Zinc-finger |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:6807888] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9829221] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | Nbr1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | NBR1_MOUSE Q9JIH9 |
| sequenceLength | 988 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:9666412] Nbr1 [peroxisomal membrane] [Mus musculus] [EntityWithAccessionedSequence:9666414] Nbr1 [cytosol] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:P97432 Nbr1 (94716)
