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Details on Person UniProt:Q96L50 LRR1
| Class:Id | ReferenceGeneProduct:94512 |
|---|---|
| _chainChangeLog | chain:1-414 added on Sat February 7 2015 |
| _displayName | UniProt:Q96L50 LRR1 |
| _timestamp | 2024-11-03 19:46:48 |
| chain | chain:1-414 |
| checksum | B19B178D6CB33C4C |
| comment | FUNCTION Substrate recognition subunit of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820). ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase (By similarity). May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1 (PubMed:11804328).PATHWAY Protein modification; protein ubiquitination.SUBUNIT Component of the probable ECS(LRR1) E3 ubiquitin-protein ligase complex which contains CUL2, RBX1, Elongin BC complex and LRR1. Interacts with CUL2, RBX1, ELOB and ELOC.INTERACTION Ubiquitous. Maximal expression was seen in the heart and skeletal muscle and minimal expression seen in the kidney.SEQUENCE CAUTION Extended N-terminus. |
| description | recommendedName: Leucine-rich repeat protein 1 alternativeName: 4-1BB-mediated-signaling molecule alternativeName: 4-1BBlrr alternativeName: LRR-repeat protein 1 shortName: LRR-1 alternativeName: Peptidylprolyl isomerase-like 5 |
| geneName | LRR1 PPIL5 |
| identifier | Q96L50 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Leucine-rich repeat Nucleus Proteomics identification Reference proteome Repeat Ubl conjugation pathway |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | LRR1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8998974] ENSEMBL:ENSG00000165501 LRR1 [Homo sapiens] |
| secondaryIdentifier | LLR1_HUMAN A5D6X3 B4DDE0 Q52M24 Q86SZ1 Q8N6H9 |
| sequenceLength | 414 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:149732] UniProt:Q96L50-2 LRR1 [Homo sapiens] [ReferenceIsoform:412900] UniProt:Q96L50-1 LRR1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:976019] LRR1 [cytosol] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q96L50 LRR1 (94512)
