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Details on Person UniProt:Q05652 pll

Class:Id	ReferenceGeneProduct:94054
_chainChangeLog	chain:1-501 added on Fri February 6 2015
_displayName	UniProt:Q05652 pll
_timestamp	2025-02-21 19:49:22
chain	chain:1-501
checksum	4B29E2B40ACB81A8
comment	FUNCTION Plays an essential role in the Tl receptor signaling pathway that establishes embryonic dorsoventral polarity; the signal directs import of dl into ventral and ventrolateral nuclei, thereby establishing dorsoventral polarity. Tub recruits pll to the plasma membrane and protein-protein interaction activates pll.CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)SUBUNIT Interacts (via Death domain) with tub (via Death domain). Interacts with Pellino (Pli).INTERACTION Associates with the plasma membrane during interphase syncytial blastoderm embryos, more specifically at the membrane invaginations around the nuclei.DEVELOPMENTAL STAGE Expressed both maternally and zygotically with low levels of expression throughout the life cycle.SIMILARITY Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.SEQUENCE CAUTION Truncated C-terminus.
description	recommendedName: Serine/threonine-protein kinase pelle ecNumber evidence="9"2.7.11.1
geneName	pll CG5974
identifier	Q05652
isSequenceChanged	FALSE
keyword	3D-structure ATP-binding Cell membrane Cytoplasm Kinase Membrane Nucleotide-binding Reference proteome Serine/threonine-protein kinase Transferase
modified	[InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9627708] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name	pll
referenceDatabase	[ReferenceDatabase:2] UniProt
secondaryIdentifier	KPEL_DROME B8A3X2 Q8T005 Q9VB57
sequenceLength	501
species	[Species:56210] Drosophila melanogaster
(referenceEntity)	[EntityWithAccessionedSequence:206070] PLL [cytosol] [Drosophila melanogaster] [EntityWithAccessionedSequence:206109] Phospho PLL [cytosol] [Drosophila melanogaster]
(referenceSequence)	[ModifiedResidue:214739] phosphorylated residue at unknown position
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No pathways have been reviewed or authored by UniProt:Q05652 pll (94054)