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Details on Person UniProt:Q61771 Kif3b
| Class:Id | ReferenceGeneProduct:93830 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:1-747 added on Fri February 6 2015;chain:2-747 added on Fri February 6 2015;initiator methionine:1 for 93830 removed on Fri Nov 03 2023;initiator methionine: for 93830 added on Fri Nov 03 2023;initiator methionine: for 93830 removed on Fri Aug 15 2025;initiator methionine:1 for 93830 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q61771 Kif3b |
| _timestamp | 2025-08-15 22:01:26 |
| chain | chain:1-747 initiator methionine:1 chain:2-747 |
| checksum | FA369A4190EC8B47 |
| comment | FUNCTION Microtubule-based molecular motor that transport intracellular cargos, such as vesicles, organelles and protein complexes. Uses ATP hydrolysis to generate force to bind and move along the microtubule (PubMed:7559760). Plays a role in cilia formation (PubMed:9865700). Involved in photoreceptor integrity and opsin trafficking in rod photoreceptors (By similarity). Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit GRIN2A into neuronal dendrites (PubMed:31746486).SUBUNIT Heterodimer of KIF3A and KIF3B (PubMed:7559760). KIF3A/KIF3B heterodimer interacts with KIFAP3 forming a heterotrimeric (KIF3A/KIF3B/KIFAP3) complex (PubMed:8710890). Interacts with the SMC3 subunit of the cohesin complex (By similarity). Interacts directly with IFT20 (PubMed:12821668). Interacts with FLCN (By similarity).INTERACTION Colocalized with GRIN2A in dendritic shafts and in DLG4-positive spines.DISRUPTION PHENOTYPE Deficient mice do not survive beyond midgestation, exhibiting growth retardation, pericardial sac ballooning, and neural tube disorganization (PubMed:9865700). Kif3b +/- mice exhibit schizophrenia-like phenotypes, both behaviorally and histologically. Hippocampal neurons have altered spine morphology and synapse function, and at the cellular level, they display abnormal growth cone morphology (PubMed:31746486).SIMILARITY Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily. |
| description | recommendedName: Kinesin-like protein KIF3B alternativeName: Microtubule plus end-directed kinesin motor 3B component recommendedName: Kinesin-like protein KIF3B, N-terminally processed /component |
| geneName | Kif3b |
| identifier | Q61771 |
| isSequenceChanged | FALSE |
| keyword | Acetylation ATP-binding Cell projection Coiled coil Cytoplasm Cytoskeleton Microtubule Motor protein Nucleotide-binding Reference proteome Synapse |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5263031] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8944791] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9688885] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9796772] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | Kif3b |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | KIF3B_MOUSE Q3UFZ8 Q8BNH4 |
| sequenceLength | 747 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:984650] Kinesin-like protein Kif3b [cytosol] [Mus musculus] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q61771 Kif3b (93830)
