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Details on Person 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity

Class:IdGO_MolecularFunction:937889
_displayName8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
_timestamp2014-02-10 23:23:52
accession0035539
created[InstanceEdit:937668] Yung, CK
definitionCatalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate (8-oxo-dGTP) + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate (8-oxo-dGMP) + diphosphate. 8-oxo-dGTP is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA.
ecNumber3.6.1.55
modified[InstanceEdit:1042299] Yung, CK
[InstanceEdit:1220942] Yung, CK
[InstanceEdit:1301023] Yung, CK
[InstanceEdit:1552540] Yung, CK
[InstanceEdit:1996004] Yung, CK
[InstanceEdit:2132408] Weiser, JD
[InstanceEdit:2133145] Weiser, JD
[InstanceEdit:2266147] Weiser, JD
[InstanceEdit:2454362] Weiser, JD
[InstanceEdit:2455542] Weiser, JD
[InstanceEdit:2587907] Weiser, JD
[InstanceEdit:3132285] Weiser, JD
[InstanceEdit:3445953] Weiser, JD
[InstanceEdit:4341211] Weiser, JD
[InstanceEdit:5083267] Weiser, JD
[InstanceEdit:5263134] Weiser, JD
[InstanceEdit:9658105] Weiser, JD, 2019-08-09
[InstanceEdit:9666277] Weiser, JD, 2019-11-04
[InstanceEdit:9676538] Cook, Justin, 2020-02-17
name8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
referenceDatabase[ReferenceDatabase:1] GO
(activity)[CatalystActivity:2395845] 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity of NUDT1 [cytosol]
[CatalystActivity:2395882] 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity of NUDT15 [cytosol]
[CatalystActivity:9750597] 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity of NUDT15 dimer [cytosol]
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