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Details on Person Notch receptor processing, ligand-dependent

Class:Id	GO_BiologicalProcess:937686
_displayName	Notch receptor processing, ligand-dependent
_timestamp	2014-02-11 01:57:37
accession	0035333
created	[InstanceEdit:937668] Yung, CK
definition	The proteolytic cleavages to the Notch protein that occur as a result of ligand binding. Ligand binding at the cell surface exposes an otherwise inaccessible cleavage site in the extracellular portion of Notch, which when cleaved releases a membrane-tethered form of the Notch intracellular domain. Subsequent cleavage within the transmembrane domain then leads to the release of the soluble Notch intracellular domain (NICD).
modified	[InstanceEdit:1042299] Yung, CK [InstanceEdit:1220942] Yung, CK [InstanceEdit:1301023] Yung, CK [InstanceEdit:1552540] Yung, CK [InstanceEdit:1996004] Yung, CK [InstanceEdit:2132408] Weiser, JD [InstanceEdit:2133145] Weiser, JD [InstanceEdit:2266147] Weiser, JD [InstanceEdit:2454362] Weiser, JD [InstanceEdit:2455542] Weiser, JD [InstanceEdit:2587907] Weiser, JD [InstanceEdit:3132285] Weiser, JD [InstanceEdit:3445953] Weiser, JD [InstanceEdit:4341211] Weiser, JD [InstanceEdit:5083267] Weiser, JD [InstanceEdit:5263134] Weiser, JD [InstanceEdit:9658105] Weiser, JD, 2019-08-09 [InstanceEdit:9666277] Weiser, JD, 2019-11-04 [InstanceEdit:9676538] Cook, Justin, 2020-02-17
name	Notch receptor processing, ligand-dependent
referenceDatabase	[ReferenceDatabase:1] GO
(goBiologicalProcess)	[Reaction:9013284] NOTCH3-ligand complex is cleaved to produce NEXT3 [Homo sapiens] [Reaction:9013361] NEXT3 is cleaved to produce NICD3 [Homo sapiens] [BlackBoxEvent:9017817] Gamma-secretase cleaves YBX1:NOTCH3 [Homo sapiens] [BlackBoxEvent:9604264] ADAM10 cleaves NOTCH4 [Homo sapiens] [Reaction:9604294] Gamma-secretase cleaves NOTCH4 [Homo sapiens]
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No pathways have been reviewed or authored by Notch receptor processing, ligand-dependent (937686)