Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:P0CG37 CFC1
| Class:Id | ReferenceGeneProduct:937580 |
|---|---|
| _chainChangeLog | signal peptide:1-25 added on Sat February 7 2015;chain:26-158 added on Sat February 7 2015;propeptide:159-223 added on Sat February 7 2015 |
| _displayName | UniProt:P0CG37 CFC1 |
| _timestamp | 2024-08-09 18:59:51 |
| chain | signal peptide:1-25 chain:26-158 propeptide:159-223 |
| checksum | B52852A00ABCF1A3 |
| comment | FUNCTION NODAL coreceptor involved in the correct establishment of the left-right axis. May play a role in mesoderm and/or neural patterning during gastrulation.SUBCELLULAR LOCATION Does not exhibit a typical GPI-signal sequence. The C-ter hydrophilic extension of the GPI-signal sequence reduces the efficiency of processing and could lead to the production of an secreted unprocessed form. This extension is found only in primates.PTM N-glycosylated.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family.CAUTION This gene differs from CFC1B by only one residue at position 78:R -> W. R78W is also thought to be a CFC1 polymorphism which has been shown to lead to a different cell surface distribution and activity (PubMed:11062482, PubMed:11799476). |
| created | [InstanceEdit:937368] Yung, CK |
| description | recommendedName: Cryptic protein alternativeName: Cryptic family protein 1 |
| geneName | CFC1 |
| identifier | P0CG37 |
| isSequenceChanged | FALSE |
| keyword | Cell membrane Developmental protein Disease variant Disulfide bond EGF-like domain Gastrulation Glycoprotein GPI-anchor Heterotaxy Lipoprotein Membrane Reference proteome Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 |
| name | CFC1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8988873] ENSEMBL:ENSG00000136698 CFC1 [Homo sapiens] |
| secondaryIdentifier | CFC1_HUMAN B2RCY0 B9EJD3 Q53T05 Q9GZR3 |
| sequenceLength | 223 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:1181327] N-aspartyl-glycosylphosphatidylinositolethanolamine-CFC1 [plasma membrane] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:1226045] N-aspartyl-glycosylphosphatidylinositolethanolamine at 158 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P0CG37 CFC1 (937580)
