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Details on Person UniProt:P0CG50 Ubc
| Class:Id | ReferenceGeneProduct:937562 |
|---|---|
| _chainChangeLog | chain:1-76 added on Fri February 6 2015;chain:77-152 added on Fri February 6 2015;chain:153-228 added on Fri February 6 2015;chain:229-304 added on Fri February 6 2015;chain:305-380 added on Fri February 6 2015;chain:381-456 added on Fri February 6 2015;chain:457-532 added on Fri February 6 2015;chain:533-608 added on Fri February 6 2015;chain:609-684 added on Fri February 6 2015;chain:685-734 added on Fri February 6 2015 |
| _displayName | UniProt:P0CG50 Ubc |
| _timestamp | 2025-08-15 21:27:24 |
| chain | chain:1-76 chain:77-152 chain:153-228 chain:229-304 chain:305-380 chain:381-456 chain:457-532 chain:533-608 chain:609-684 chain:685-734 |
| checksum | EDD9B8556FF81D5B |
| comment | FUNCTION Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. During ubiquitination, the acceptor ubiquitin is positioned in the active site via direct interaction with the E2 ubiquitin-conjugating enzymes such as UBE2R2 (By similarity). As a monoubiquitin, its C-terminal glycine is recognized as a C-degron by Cul2-RING (CRL2) E3 ubiquitin-protein ligase complexes (By similarity).SUBCELLULAR LOCATION Phosphorylated at Ser-65 by PINK1 during mitophagy. Phosphorylated ubiquitin specifically binds and activates parkin (PRKN), triggering mitophagy. Phosphorylation does not affect E1-mediated E2 charging of ubiquitin but affects discharging of E2 enzymes to form polyubiquitin chains. It also affects deubiquitination by deubiquitinase enzymes such as USP30.PTM Mono-ADP-ribosylated at the C-terminus by PARP9, a component of the PPAR9-DTX3L complex. ADP-ribosylation requires processing by E1 and E2 enzymes and prevents ubiquitin conjugation to substrates such as histones.MISCELLANEOUS Ubiquitin is encoded by 4 different genes. Uba52 and Rps27a genes code for a single copy of ubiquitin fused to the ribosomal proteins eL40 and eS31, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.MISCELLANEOUS For the sake of clarity sequence features are annotated only for the first chain, and are not repeated for each of the following chains.SIMILARITY Belongs to the ubiquitin family. |
| created | [InstanceEdit:937368] Yung, CK |
| description | recommendedName: Polyubiquitin-C component recommendedName: Ubiquitin /component component recommendedName: Ubiquitin-related 1 /component component recommendedName: Ubiquitin-related 2 /component |
| geneName | Ubc |
| identifier | P0CG50 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure ADP-ribosylation Cytoplasm Isopeptide bond Membrane Mitochondrion Mitochondrion outer membrane Nucleus Phosphoprotein Reference proteome Repeat Ubl conjugation |
| modified | [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5263031] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9027688] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9773244] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | Ubc |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | UBC_MOUSE E9QKI0 P02248 P02249 P02250 P62991 Q29120 Q62317 Q64223 Q8VCH1 Q91887 Q91888 Q9CXY4 Q9CZM0 Q9D1R5 Q9D8D9 Q9ET23 Q9ET24 Q9Z0H9 |
| sequenceLength | 734 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:940359] Ubiquitin (Ubc 4) [cytosol] [Mus musculus] [EntityWithAccessionedSequence:940360] Ubiquitin (Ubc 5) [cytosol] [Mus musculus] [EntityWithAccessionedSequence:940362] Ubiquitin (Ubc 3) [cytosol] [Mus musculus] [EntityWithAccessionedSequence:940368] Ubiquitin (Ubc 5) [nucleoplasm] [Mus musculus] [EntityWithAccessionedSequence:940371] Ubiquitin (Ubc 7) [cytosol] [Mus musculus] [EntityWithAccessionedSequence:940372] Ubiquitin related 2 (Ubc r2) [nucleoplasm] [Mus musculus] [EntityWithAccessionedSequence:940373] Ubiquitin related 2 (Ubc r2) [cytosol] [Mus musculus] [EntityWithAccessionedSequence:940374] Ubiquitin (Ubc 2) [nucleoplasm] [Mus musculus] [EntityWithAccessionedSequence:940375] Ubiquitin (Ubc 8) [nucleoplasm] [Mus musculus] [EntityWithAccessionedSequence:940376] Ubiquitin (Ubc 1) [nucleoplasm] [Mus musculus] |
| (referenceSequence) | [ModifiedResidue:9932591] ubiquitinylated lysine at 428 [ModifiedResidue:9932597] ubiquitinylated lysine at 580 [ModifiedResidue:9932598] ubiquitinylated lysine at 124 [ModifiedResidue:9932612] ubiquitinylated lysine at 732 [ModifiedResidue:9932625] ubiquitinylated lysine at 504 [ModifiedResidue:9932627] ubiquitinylated lysine at 200 [ModifiedResidue:9932631] ubiquitinylated lysine at 276 [ModifiedResidue:9932637] ubiquitinylated lysine at 352 [ModifiedResidue:9932654] ubiquitinylated lysine at 656 [ModifiedResidue:9932665] ubiquitinylated lysine at 48 |
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No pathways have been reviewed or authored by UniProt:P0CG50 Ubc (937562)
