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Details on Person NLRC5 interacts with DDX58/IFIH1

Class:Id	Reaction:937343
_displayName	NLRC5 interacts with DDX58/IFIH1
_doRelease	TRUE
_timestamp	2023-05-18 14:07:18
authored	[InstanceEdit:918228] Garapati, P V, 2010-08-02
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:937327] Garapati, P V, 2010-08-26
edited	[InstanceEdit:918228] Garapati, P V, 2010-08-02
input	[EntityWithAccessionedSequence:937324] NLRC5 [cytosol] [Homo sapiens] [DefinedSet:918192] viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:937326] NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways
modified	[InstanceEdit:990524] Garapati, P V, 2010-11-03 [InstanceEdit:994081] Garapati, P V, 2010-11-05 [InstanceEdit:998145] Garapati, P V, 2010-11-09 [InstanceEdit:1022090] Garapati, P V, 2010-11-17 [InstanceEdit:1028822] Garapati, P V, 2010-11-18 [InstanceEdit:8983918] Jupe, Steve, 2017-03-31 [InstanceEdit:9014715] Shamovsky, Veronica, 2017-08-02 [InstanceEdit:9031715] D'Eustachio, Peter, 2017-12-01 [InstanceEdit:9031726] D'Eustachio, Peter, 2017-12-01 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9835834] Shamovsky, Veronica, 2023-05-18
name	NLRC5 interacts with DDX58/IFIH1 NLRC5 interacts with RIG-I/MDA5 and inhibit IPS-1 binding
output	[Complex:937325] viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP:NLRC5 [cytosol] [Homo sapiens]
relatedSpecies	[Species:5621375] Hepatitis C Virus [Species:9013948] Measles virus [Species:5617433] Rotavirus [Species:9031716] Influenza A virus [Species:9717528] Human respiratory syncytial virus A
releaseDate	2010-12-14
reviewed	[InstanceEdit:990527] Kawai, T, Akira, S, 2010-10-30
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104803] R-HSA-937343.5
summation	[Summation:937331] NLRC5 competes with MAVS (IPS-1) for binding to the CARD dom...
(hasEvent)	[Pathway:936440] Negative regulators of DDX58/IFIH1 signaling [Homo sapiens]
(inferredFrom)	[Reaction:1227695] NLRC5 binds to CARD domain of Mda5 and prevents IPS1 binding [Gallus gallus]
(updatedInstance)	[_UpdateTracker:9928451] Update Tracker - [Reaction:937343] NLRC5 interacts with DDX58/IFIH1 - v91:[modifyText]
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No pathways have been reviewed or authored by NLRC5 interacts with DDX58/IFIH1 (937343)