Query author contributions in Reactome
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Details on Person NLRC5 competes with MAVS (IPS-1) for binding to the CARD dom...
| Class:Id | Summation:937331 |
|---|---|
| _displayName | NLRC5 competes with MAVS (IPS-1) for binding to the CARD dom... |
| _timestamp | 2024-11-05 11:22:04 |
| created | [InstanceEdit:937327] Garapati, P V, 2010-08-26 |
| literatureReference | [LiteratureReference:937326] NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways |
| modified | [InstanceEdit:9927237] Shamovsky, Veronica, 2024-11-05 |
| text | NLRC5 competes with MAVS (IPS-1) for binding to the CARD domain of RIG-I (DDX58) and/or MDA5 (IFIH1). NLRC5 specifically recognize the CARD domains of DDX58/IFIH1 when the CARD domains become accessible after viral infection, leading to dampened activation of IRF3. |
| (summation) | [Reaction:168909] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS [Homo sapiens] [Reaction:937343] NLRC5 interacts with DDX58/IFIH1 [Homo sapiens] |
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No pathways have been reviewed or authored by NLRC5 competes with MAVS (IPS-1) for binding to the CARD dom... (937331)
