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Details on Person UniProt:P19454 CKA2
| Class:Id | ReferenceGeneProduct:93708 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-339 added on Fri February 6 2015;initiator methionine:1 for 93708 removed on Fri Nov 03 2023;initiator methionine: for 93708 added on Fri Nov 03 2023;initiator methionine: for 93708 removed on Fri Aug 15 2025;initiator methionine:1 for 93708 added on Fri Aug 15 2025 |
| _displayName | UniProt:P19454 CKA2 |
| _timestamp | 2025-08-15 21:44:28 |
| chain | initiator methionine:1 chain:2-339 |
| checksum | 30E214BD852824D0 |
| comment | FUNCTION Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (By similarity). Phosphorylates YTA7 during S-phase to promote transcription of histones (PubMed:22156209).CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)SUBUNIT Tetramer composed of an alpha chain, an alpha', one beta chain and one beta' chain (PubMed:12242279). Interacts with FACT subunits POB3 and SPT16 (PubMed:12242279). Interacts with NAP1 (PubMed:18086883). Interacts with YTA7 (PubMed:22156209).INTERACTION Present with 4540 molecules/cell in log phase SD medium.SIMILARITY Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily. |
| description | recommendedName: Casein kinase II subunit alpha' shortName: CK II ecNumber evidence="1"2.7.11.1 |
| geneName | CKA2 YOR061W YOR29-12 |
| identifier | P19454 |
| isSequenceChanged | FALSE |
| keyword | ATP-binding Direct protein sequencing Kinase Nucleotide-binding Reference proteome Serine/threonine-protein kinase Transferase |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9773244] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | CKA2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | CSK22_YEAST D6W2C4 |
| sequenceLength | 339 |
| species | [Species:68322] Saccharomyces cerevisiae |
| (referenceEntity) | [EntityWithAccessionedSequence:6790631] CKA2 [nucleoplasm] [Saccharomyces cerevisiae] |
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No pathways have been reviewed or authored by UniProt:P19454 CKA2 (93708)
