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Details on Person MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88

Class:IdReaction:937079
_displayNameMyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88
_doReleaseTRUE
_timestamp2018-08-09 02:30:31
authored[InstanceEdit:847735] Shamovsky, V, 2010-06-01
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:937077] Shamovsky, V, 2010-08-25
edited[InstanceEdit:2562589] Shamovsky, V, 2012-11-06
input[EntityWithAccessionedSequence:166059] MYD88 [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:166059] MYD88 [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:166059] MYD88 [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:166059] MYD88 [cytosol] [Homo sapiens]
[Complex:166062] MyD88:TIRAP:BTK:activated TLR2/4 [plasma membrane] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:937049] Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling
[LiteratureReference:936987] An oligomeric signaling platform formed by the Toll-like receptor signal transducers MyD88 and IRAK-4
[LiteratureReference:2428864] Two human MYD88 variants, S34Y and R98C, interfere with MyD88-IRAK4-myddosome assembly
modified[InstanceEdit:1018388] Shamovsky, V, 2010-11-16
[InstanceEdit:1094899] Shamovsky, V, 2010-11-29
[InstanceEdit:1095195] Shamovsky, V, 2010-11-30
[InstanceEdit:1564964] Shamovsky, V, 2011-09-06
[InstanceEdit:1602499] Shamovsky, V, 2011-09-14
[InstanceEdit:2428906] Shamovsky, V, 2012-08-08
[InstanceEdit:2603276] Shamovsky, V, 2012-11-19
[InstanceEdit:2627685] Shamovsky, V, 2012-11-19
[InstanceEdit:5621483] Shamovsky, V, 2014-08-29
[InstanceEdit:9615894] Shamovsky, Veronica, 2018-08-09
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameMyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88
MyD88 oligomerization within the complex of activated TLR:MAL:MyD88
output[Complex:937033] oligo-MyD88:TIRAP:BTK:activated TLR [plasma membrane] [Homo sapiens]
precedingEvent
relatedSpecies[Species:180800] Neisseria meningitidis serogroup B
[Species:181384] Chlamydia trachomatis
releaseDate2010-12-14
reviewed[InstanceEdit:1095192] Gillespie, ME, 2010-11-30
[InstanceEdit:2603254] Napetschnig, Johanna, 2012-11-16
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1105230] R-HSA-937079.3
summation[Summation:937062] Structural analysis of MyD88:IRAK4 and MyD88:IRAK4:IRAK2 sug...
(hasEvent)[Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane [Homo sapiens]
(normalReaction)[FailedReaction:5602383] Defective MyD88 does not oligomerize within the activated TLR2/4 complex [Homo sapiens]
(precedingEvent)[Reaction:166082] IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex [Homo sapiens]
(updatedInstance)[_UpdateTracker:9788162] Update Tracker - [Reaction:937079] MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 - v43:[modifyText]
[_UpdateTracker:9788407] Update Tracker - [Reaction:937079] MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 - v42:[addLiteratureReference, modifyText]
[_UpdateTracker:9789566] Update Tracker - [Reaction:937079] MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 - v37:[modifyText]
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No pathways have been reviewed or authored by MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 (937079)
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