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Details on Person Phosphorylated TAK1 leaves activated TLR receptor complex
Class:Id Reaction:937075 _displayName Phosphorylated TAK1 leaves activated TLR receptor complex _doRelease TRUE _timestamp 2017-08-01 19:47:18 authored [InstanceEdit:937113] Shamovsky, V, 2010-08-25 compartment [Compartment:70101] cytosol [Compartment:74700] endosome membrane created [InstanceEdit:937065] Shamovsky, V, 2010-08-25 edited [InstanceEdit:1485578] Shamovsky, V, 2011-08-12 input [Complex:936946] activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:activated TAK1 complex [endosome membrane] [Homo sapiens] isChimeric FALSE literatureReference [LiteratureReference:177899] Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR [LiteratureReference:169927] Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol modified [InstanceEdit:1018389] Shamovsky, V, 2010-11-16 [InstanceEdit:1094899] Shamovsky, V, 2010-11-29 [InstanceEdit:1095195] Shamovsky, V, 2010-11-30 [InstanceEdit:1564968] Shamovsky, V, 2011-09-06 [InstanceEdit:1602499] Shamovsky, V, 2011-09-14 [InstanceEdit:2201354] Shamovsky, V, 2012-04-19 [InstanceEdit:2248857] Shamovsky, V, 2012-05-15 [InstanceEdit:2582979] Shamovsky, V, 2012-11-13 [InstanceEdit:2632486] Shamovsky, V, 2012-11-20 [InstanceEdit:2632490] Shamovsky, V, 2012-11-20 [InstanceEdit:5566478] Shamovsky, V, 2014-05-23 [InstanceEdit:9014560] Shamovsky, Veronica, 2017-08-01 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 name Phosphorylated TAK1 leaves activated TLR receptor complex output [Complex:847073] K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] [Homo sapiens] [Complex:166172] TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] [Homo sapiens] precedingEvent
releaseDate 2010-12-14 reviewed [InstanceEdit:1095192] Gillespie, ME, 2010-11-30 [InstanceEdit:2582977] Fitzgerald, Katherine A, 2012-11-13 reviewStatus [ReviewStatus:9821382] five stars species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:1105093] R-HSA-937075.3 summation [Summation:937054] Phosphorylated TAK1 complexed with TRAF6-TAB1-TAB2/TAB3 leav... (hasEvent) [Pathway:937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex [Homo sapiens] (inferredFrom) [Reaction:1008270] Activated TAK1 leaves endosome membrane [Gallus gallus] (updatedInstance) [_UpdateTracker:9780582] Update Tracker - [Reaction:937075] Phosphorylated TAK1 leaves activated TLR receptor complex - v62:[add_removeOutput] [_UpdateTracker:9788696] Update Tracker - [Reaction:937075] Phosphorylated TAK1 leaves activated TLR receptor complex - v41:[add_removeOutput]
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