Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane]

Class:IdComplex:937048
_displayNamep-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane]
_timestamp2018-08-09 02:31:41
compartment[Compartment:876] plasma membrane
created[InstanceEdit:937009] Shamovsky, V, 2010-08-25
hasComponent
literatureReference[LiteratureReference:936987] An oligomeric signaling platform formed by the Toll-like receptor signal transducers MyD88 and IRAK-4
[LiteratureReference:937049] Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling
modified[InstanceEdit:1564982] Shamovsky, V, 2011-09-06
[InstanceEdit:2428907] Shamovsky, V, 2012-08-08
[InstanceEdit:8959586] Weiser, JD
[InstanceEdit:9615894] Shamovsky, Veronica, 2018-08-09
namep-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor
relatedSpecies[Species:181384] Chlamydia trachomatis
[Species:180800] Neisseria meningitidis serogroup B
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1111298] R-HSA-937048.3
(hasComponent)[Complex:166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane] [Homo sapiens]
[Complex:166118] p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] [Homo sapiens]
[Complex:166360] p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] [Homo sapiens]
[Complex:937018] IRAK1:p-S,2T-IRAK4 :oligo-MyD88:TIRAP:activated TLR [plasma membrane] [Homo sapiens]
[Complex:937028] IRAK2:p-S,2T-IRAK4:oligo-MyD88:Mal:activated TLR [plasma membrane] [Homo sapiens]
[Complex:937055] p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] [Homo sapiens]
[Complex:937067] hp-IRAK1 or p-IRAK2:pIRAK4:MyD88:Mal:activated TLR complex [plasma membrane] [Homo sapiens]
(input)[Reaction:166091] IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex [Homo sapiens]
(output)[Reaction:166362] Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex [Homo sapiens]
[Reaction:937022] IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP [Homo sapiens]
[Reaction:2262775] Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex [Homo sapiens]
(updatedInstance)[_UpdateTracker:9870353] Update Tracker - [Complex:937048] p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] - v38:[modifyName]
[_UpdateTracker:9871139] Update Tracker - [Complex:937048] p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] - v39:[updateContainedComponent]
[_UpdateTracker:9872369] Update Tracker - [Complex:937048] p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] - v41:[updateContainedComponent]
[_UpdateTracker:9873166] Update Tracker - [Complex:937048] p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] - v42:[addLiteratureReference, updateContainedComponent]
[_UpdateTracker:9873802] Update Tracker - [Complex:937048] p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] - v43:[updateContainedComponent]
[_UpdateTracker:9889634] Update Tracker - [Complex:937048] p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] - v49:[updateContainedComponent]
[_UpdateTracker:9891076] Update Tracker - [Complex:937048] p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] - v52:[updateContainedComponent]
[_UpdateTracker:9893008] Update Tracker - [Complex:937048] p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] - v54:[updateContainedComponent]
[_UpdateTracker:9895262] Update Tracker - [Complex:937048] p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] - v59:[updateContainedComponent]
[_UpdateTracker:9896431] Update Tracker - [Complex:937048] p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] - v60:[removeSpecies, updateContainedComponent]
List all 13 refering instances
[Change default viewing format]
No pathways have been reviewed or authored by p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] (937048)
Follow Reactome