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Details on Person TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol]

Class:Id	Complex:937038
_displayName	TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol]
_timestamp	2012-08-08 19:31:38
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:937009] Shamovsky, V, 2010-08-25
hasComponent	[Complex:168113] CHUK:IKBKB:IKBKG [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:168104] CHUK [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:168114] IKBKB [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:168108] IKBKG [cytosol] [Homo sapiens] [Complex:937043] K63-linked polyUb p-IRAK1:TRAF6 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:451565] K63polyUb-hp-IRAK1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:166366] TRAF6 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:450158] Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activation [LiteratureReference:2428811] Endotoxin tolerance impairs IL-1 receptor-associated kinase (IRAK) 4 and TGF-beta-activated kinase 1 activation, K63-linked polyubiquitination and assembly of IRAK1, TNF receptor-associated factor 6, and IkappaB kinase gamma and increases A20 expression
modified	[InstanceEdit:2428906] Shamovsky, V, 2012-08-08
name	TRAF6:K63-linked polyUb p-IRAK1:IKK complex
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1108322] R-HSA-937038.1
(output)	[Reaction:937032] NEMO subunit of IKK complex binds to activated IRAK1 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9870825] Update Tracker - [Complex:937038] TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] - v38:[updateContainedComponent] [_UpdateTracker:9873311] Update Tracker - [Complex:937038] TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] - v42:[addLiteratureReference] [_UpdateTracker:9876307] Update Tracker - [Complex:937038] TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] - v44:[updateContainedComponent] [_UpdateTracker:9894350] Update Tracker - [Complex:937038] TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] - v57:[updateContainedComponent] [_UpdateTracker:9896614] Update Tracker - [Complex:937038] TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] - v60:[updateContainedComponent]
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No pathways have been reviewed or authored by TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (937038)