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Details on Person NEMO subunit of IKK complex binds to activated IRAK1

Class:Id	Reaction:937032
_displayName	NEMO subunit of IKK complex binds to activated IRAK1
_doRelease	TRUE
_timestamp	2012-11-19 21:55:48
authored	[InstanceEdit:847735] Shamovsky, V, 2010-06-01
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:937009] Shamovsky, V, 2010-08-25
edited	[InstanceEdit:2562589] Shamovsky, V, 2012-11-06
input	[Complex:937043] K63-linked polyUb p-IRAK1:TRAF6 [cytosol] [Homo sapiens] [Complex:168113] CHUK:IKBKB:IKBKG [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:451426] Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase [LiteratureReference:451569] Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected] [LiteratureReference:450158] Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activation
modified	[InstanceEdit:940400] Shamovsky, V, 2010-09-02 [InstanceEdit:1018388] Shamovsky, V, 2010-11-16 [InstanceEdit:1094899] Shamovsky, V, 2010-11-29 [InstanceEdit:1095195] Shamovsky, V, 2010-11-30 [InstanceEdit:2603278] Shamovsky, V, 2012-11-19 [InstanceEdit:2627685] Shamovsky, V, 2012-11-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NEMO subunit of IKK complex binds to activated IRAK1
output	[Complex:937038] TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] [Homo sapiens]
precedingEvent	[Reaction:937050] Pellino ubiquitinates hp-IRAK1 [Homo sapiens] [Reaction:937034] IRAK1 phosphorylates Pellino [Homo sapiens]
releaseDate	2010-12-14
reviewed	[InstanceEdit:1095192] Gillespie, ME, 2010-11-30 [InstanceEdit:2603254] Napetschnig, Johanna, 2012-11-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105579] R-HSA-937032.2
summation	[Summation:451573] NF-kappa-B essential modulator (NEMO, also known as IKKG abb...
(hasEvent)	[Pathway:937039] IRAK1 recruits IKK complex [Homo sapiens]
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No pathways have been reviewed or authored by NEMO subunit of IKK complex binds to activated IRAK1 (937032)