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Details on Person IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP
Class:Id Reaction:937022 _displayName IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP _doRelease TRUE _timestamp 2018-08-09 02:30:10 authored [InstanceEdit:847735] Shamovsky, V, 2010-06-01 catalystActivity [CatalystActivity:937019] protein serine/threonine kinase activity of IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] catalystActivityReference [CatalystActivityReference:9643282] protein serine/threonine kinase activity of IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] IRAK-4: a novel member of the IRAK family with the properties of an compartment [Compartment:70101] cytosol [Compartment:876] plasma membrane created [InstanceEdit:937009] Shamovsky, V, 2010-08-25 edited [InstanceEdit:2562589] Shamovsky, V, 2012-11-06 input [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [Complex:166080] IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] [Homo sapiens] isChimeric FALSE literatureReference [LiteratureReference:446630] Regulation of IRAK-4 kinase activity via autophosphorylation within its activation loop [LiteratureReference:937035] Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling modified [InstanceEdit:1018389] Shamovsky, V, 2010-11-16 [InstanceEdit:1094899] Shamovsky, V, 2010-11-29 [InstanceEdit:1095194] Shamovsky, V, 2010-11-30 [InstanceEdit:1564953] Shamovsky, V, 2011-09-06 [InstanceEdit:1602499] Shamovsky, V, 2011-09-14 [InstanceEdit:2603271] Shamovsky, V, 2012-11-19 [InstanceEdit:2627684] Shamovsky, V, 2012-11-19 [InstanceEdit:5621483] Shamovsky, V, 2014-08-29 [InstanceEdit:9615894] Shamovsky, Veronica, 2018-08-09 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 name IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP output [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [Complex:937048] p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] [Homo sapiens] precedingEvent
relatedSpecies [Species:180800] Neisseria meningitidis serogroup B [Species:181384] Chlamydia trachomatis releaseDate 2010-12-14 reviewed [InstanceEdit:1095192] Gillespie, ME, 2010-11-30 [InstanceEdit:2603254] Napetschnig, Johanna, 2012-11-16 reviewStatus [ReviewStatus:9821382] five stars species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:1104755] R-HSA-937022.4 summation [Summation:446631] IRAK4 is activated by autophosphorylation at 3 positions wit... (hasEvent) [Pathway:166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane [Homo sapiens] (inferredFrom) [Reaction:434018] Autophosphorylation of chicken IRAK4 [Gallus gallus] (precedingEvent) [Reaction:166091] IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex [Homo sapiens]
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No pathways have been reviewed or authored by IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP (937022)
