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Details on Person UniProt:Q9JMK2 Csnk1e
| Class:Id | ReferenceGeneProduct:93700 |
|---|---|
| _chainChangeLog | chain:1-416 added on Fri February 6 2015 |
| _displayName | UniProt:Q9JMK2 Csnk1e |
| _timestamp | 2025-08-15 21:00:36 |
| chain | chain:1-416 |
| checksum | 38CC5299BB9040D7 |
| comment | FUNCTION Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (By similarity). Participates in Wnt signaling (By similarity). Phosphorylates DVL1 (By similarity). Phosphorylates DVL2 (By similarity). Phosphorylates NEDD9/HEF1 (PubMed:29191835). Central component of the circadian clock (PubMed:18400165, PubMed:19414593, PubMed:21930935). In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation (PubMed:18400165, PubMed:19414593, PubMed:21930935). Controls PER1 and PER2 nuclear transport and degradation (PubMed:10848614, PubMed:14701732, PubMed:18400165, PubMed:19414593, PubMed:21930935). Inhibits cytokine-induced granuloytic differentiation (By similarity).CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)ACTIVITY REGULATION Phosphorylation leads to a decrease in the catalytic activity.SUBUNIT Monomer (By similarity). Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, ARTNL/BMAL1 or ARTNL2/BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins (PubMed:11779462). Interacts with ANKRD6 (PubMed:12183362). Interacts with PER1 (By similarity). Interacts with DBNDD2, LRP5, LRP6 and SOCS3 (By similarity). Interacts with SNAI1 (via zinc fingers) (By similarity). Interacts with DDX3X; this interaction greatly enhances CSNK1E affinity for ATP and DVL2 phosphorylation, but inhibits DDX3X ATPase/helicase activity. In the presence of RNA, the interaction is decreased (By similarity). Interacts with FAM83A, FAM83B, FAM83E and FAM83H (via DUF1669) (By similarity).INTERACTION Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. Expressed in monocytes and lymphocytes but not in granulocytes.INDUCTION Down-regulated during granulocytic differentiation. Does not show circadian oscillations.PTM Autophosphorylated. Partially dephosphorylated by PPP5C. May be dephosphorylated by PP1.DISRUPTION PHENOTYPE No visible phenotype. Has no apparent effect on circadian oscillation of protein levels. Mice exhibit a small but significant increase in circadian period length.SIMILARITY Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. |
| description | recommendedName: Casein kinase I isoform epsilon shortName: CKI-epsilon shortName: CKIe ecNumber evidence="12"2.7.11.1 |
| geneName | Csnk1e |
| identifier | Q9JMK2 |
| isSequenceChanged | FALSE |
| keyword | ATP-binding Biological rhythms Cytoplasm Kinase Methylation Nucleotide-binding Nucleus Phosphoprotein Reference proteome Serine/threonine-protein kinase Transferase Wnt signaling pathway |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5083144] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8944791] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9627708] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9645058] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9688885] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9819394] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | Csnk1e |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | KC1E_MOUSE Q8R389 |
| sequenceLength | 416 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:206029] Csnk1e [cytosol] [Mus musculus] [EntityWithAccessionedSequence:508745] Csnk1e [nucleoplasm] [Mus musculus] [EntityWithAccessionedSequence:9983886] p-S389-Csnk1e [cytosol] [Mus musculus] |
| (referenceSequence) | [ModifiedResidue:9983880] O-phospho-L-serine at 389 |
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No pathways have been reviewed or authored by UniProt:Q9JMK2 Csnk1e (93700)
