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Details on Person Activated TLR4:TICAM1 recruits TRAF6

Class:Id	Reaction:936985
_displayName	Activated TLR4:TICAM1 recruits TRAF6
_doRelease	TRUE
_timestamp	2017-07-28 02:41:37
authored	[InstanceEdit:847735] Shamovsky, V, 2010-06-01
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:936971] Shamovsky, V, 2010-08-25
edited	[InstanceEdit:1485578] Shamovsky, V, 2011-08-12
input	[EntityWithAccessionedSequence:166366] TRAF6 [cytosol] [Homo sapiens] [Complex:166172] TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:500568] Direct binding of TRAF2 and TRAF6 to TICAM-1/TRIF adaptor participates in activation of the Toll-like receptor 3/4 pathway [LiteratureReference:433920] Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6 [LiteratureReference:169969] Tumor necrosis factor receptor-associated factors (TRAFs)--a family of adapter proteins that regulates life and death [LiteratureReference:208040] Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain [LiteratureReference:936978] Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif
modified	[InstanceEdit:1018387] Shamovsky, V, 2010-11-16 [InstanceEdit:1094898] Shamovsky, V, 2010-11-29 [InstanceEdit:1095193] Shamovsky, V, 2010-11-30 [InstanceEdit:1551955] Shamovsky, V, 2011-08-30 [InstanceEdit:1602499] Shamovsky, V, 2011-09-14 [InstanceEdit:2201350] Shamovsky, V, 2012-04-19 [InstanceEdit:2248854] Shamovsky, V, 2012-05-15 [InstanceEdit:2248859] Shamovsky, V, 2012-05-15 [InstanceEdit:2299704] Shamovsky, V, 2012-06-01 [InstanceEdit:2428905] Shamovsky, V, 2012-08-08 [InstanceEdit:2559579] Shamovsky, V, 2012-11-02 [InstanceEdit:2562589] Shamovsky, V, 2012-11-06 [InstanceEdit:2569090] Shamovsky, V, 2012-11-12 [InstanceEdit:2581442] Shamovsky, V, 2012-11-13 [InstanceEdit:2582979] Shamovsky, V, 2012-11-13 [InstanceEdit:2632484] Shamovsky, V, 2012-11-20 [InstanceEdit:2632490] Shamovsky, V, 2012-11-20 [InstanceEdit:9014307] Shamovsky, Veronica, 2017-07-28 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated TLR4:TICAM1 recruits TRAF6
output	[Complex:936976] TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] [Homo sapiens]
precedingEvent	[Reaction:166175] TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) [Homo sapiens] [Reaction:168929] Viral dsRNA:TLR3 recruits TRIF (TICAM1) [Homo sapiens] [Reaction:168092] Viral dsRNA binds the Toll-Like Receptor 3 (TLR3) [Homo sapiens]
regulatedBy	[NegativeRegulation:2559573] Negative regulation by 'SARM:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]'
releaseDate	2010-12-14
reviewed	[InstanceEdit:1095192] Gillespie, ME, 2010-11-30 [InstanceEdit:2582977] Fitzgerald, Katherine A, 2012-11-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104196] R-HSA-936985.4
summation	[Summation:446616] TRAF6 is recruited to the N-terminal domain of TICAM1 and th...
(hasEvent)	[Pathway:937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:936952] Auto ubiquitination of TRAF6 bound to the activated TLR4 complex [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9780719] Update Tracker - [Reaction:936985] Activated TLR4:TICAM1 recruits TRAF6 - v62:[add_removeInput] [_UpdateTracker:9788180] Update Tracker - [Reaction:936985] Activated TLR4:TICAM1 recruits TRAF6 - v43:[addRegulator, modifyText] [_UpdateTracker:9788392] Update Tracker - [Reaction:936985] Activated TLR4:TICAM1 recruits TRAF6 - v42:[addLiteratureReference] [_UpdateTracker:9788686] Update Tracker - [Reaction:936985] Activated TLR4:TICAM1 recruits TRAF6 - v41:[add_removeInput]
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