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Details on Person Auto ubiquitination of TRAF6 bound to the activated TLR4 complex

Class:Id	BlackBoxEvent:936952
_displayName	Auto ubiquitination of TRAF6 bound to the activated TLR4 complex
_doRelease	TRUE
_timestamp	2017-07-28 03:12:03
authored	[InstanceEdit:847735] Shamovsky, V, 2010-06-01
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:936971] Shamovsky, V, 2010-08-25
edited	[InstanceEdit:1018388] Shamovsky, V, 2010-11-16
input	[Complex:936976] TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:202511] Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation
modified	[InstanceEdit:1018389] Shamovsky, V, 2010-11-16 [InstanceEdit:1094898] Shamovsky, V, 2010-11-29 [InstanceEdit:1095193] Shamovsky, V, 2010-11-30 [InstanceEdit:1602499] Shamovsky, V, 2011-09-14 [InstanceEdit:2201350] Shamovsky, V, 2012-04-19 [InstanceEdit:2272820] Shamovsky, V, 2012-05-25 [InstanceEdit:2429699] Shamovsky, V, 2012-08-09 [InstanceEdit:2582979] Shamovsky, V, 2012-11-13 [InstanceEdit:2632484] Shamovsky, V, 2012-11-20 [InstanceEdit:2632490] Shamovsky, V, 2012-11-20 [InstanceEdit:2980516] Jassal, B, 2013-01-11 [InstanceEdit:2997523] Jassal, B, 2013-01-23 [InstanceEdit:3209842] Jassal, B, 2013-03-04 [InstanceEdit:9014332] Shamovsky, Veronica, 2017-07-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Auto ubiquitination of TRAF6 bound to the activated TLR4 complex
output	[Complex:936965] K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] [Homo sapiens]
precedingEvent	[Reaction:936985] Activated TLR4:TICAM1 recruits TRAF6 [Homo sapiens] [Reaction:166175] TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) [Homo sapiens] [Reaction:168929] Viral dsRNA:TLR3 recruits TRIF (TICAM1) [Homo sapiens]
releaseDate	2010-12-14
requiredInputComponent	[EntityWithAccessionedSequence:205753] UBE2V1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:206072] UBE2N [cytosol] [Homo sapiens]
reviewed	[InstanceEdit:1095192] Gillespie, ME, 2010-11-30 [InstanceEdit:2582977] Fitzgerald, Katherine A, 2012-11-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105612] R-HSA-936952.3
summation	[Summation:202446] TRAF6 possesses ubiquitin ligase activity and undergoes K-63...
(hasEvent)	[Pathway:937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex [Homo sapiens]
(precedingEvent)	[Polymerisation:450358] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation [Homo sapiens] [Reaction:936947] Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9788124] Update Tracker - [BlackBoxEvent:936952] Auto ubiquitination of TRAF6 bound to the activated TLR4 complex - v43:[modifyText] [_UpdateTracker:9789962] Update Tracker - [BlackBoxEvent:936952] Auto ubiquitination of TRAF6 bound to the activated TLR4 complex - v36:[modifyText]
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