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Details on Person Activation of TAK1 complex bound to activated TLR4 complex

Class:IdReaction:936951
_displayNameActivation of TAK1 complex bound to activated TLR4 complex
_doReleaseTRUE
_timestamp2017-07-28 03:09:32
authored[InstanceEdit:847735] Shamovsky, V, 2010-06-01
catalystActivity[CatalystActivity:936943] protein serine/threonine kinase activity of activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane]
compartment[Compartment:70101] cytosol
[Compartment:74700] endosome membrane
created[InstanceEdit:936971] Shamovsky, V, 2010-08-25
edited[InstanceEdit:1485578] Shamovsky, V, 2011-08-12
input[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[Complex:936954] activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:438014] Essential function for the kinase TAK1 in innate and adaptive immune responses
[LiteratureReference:450183] TAK1 mitogen-activated protein kinase kinase kinase is activated by autophosphorylation within its activation loop
[LiteratureReference:433972] TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo
[LiteratureReference:202523] Ubiquitin-mediated activation of TAK1 and IKK
modified[InstanceEdit:1018387] Shamovsky, V, 2010-11-16
[InstanceEdit:1094898] Shamovsky, V, 2010-11-29
[InstanceEdit:1095193] Shamovsky, V, 2010-11-30
[InstanceEdit:1564945] Shamovsky, V, 2011-09-06
[InstanceEdit:1602499] Shamovsky, V, 2011-09-14
[InstanceEdit:2201348] Shamovsky, V, 2012-04-19
[InstanceEdit:2248856] Shamovsky, V, 2012-05-15
[InstanceEdit:2429699] Shamovsky, V, 2012-08-09
[InstanceEdit:2582979] Shamovsky, V, 2012-11-13
[InstanceEdit:2632484] Shamovsky, V, 2012-11-20
[InstanceEdit:2632490] Shamovsky, V, 2012-11-20
[InstanceEdit:9014329] Shamovsky, Veronica, 2017-07-28
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameActivation of TAK1 complex bound to activated TLR4 complex
output[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[Complex:936946] activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:activated TAK1 complex [endosome membrane] [Homo sapiens]
precedingEvent
releaseDate2010-12-14
reviewed[InstanceEdit:1095192] Gillespie, ME, 2010-11-30
[InstanceEdit:2582977] Fitzgerald, Katherine A, 2012-11-13
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1105487] R-HSA-936951.3
summation[Summation:450184] The TAK1 complex consists of Transforming growth factor-beta...
(hasEvent)[Pathway:937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex [Homo sapiens]
(precedingEvent)[Reaction:168184] Activated TAK1 mediates phosphorylation of the IKK Complex [Homo sapiens]
[Reaction:450337] Activated TAK1 phosphorylates MKK4/MKK7 [Homo sapiens]
[Reaction:450346] activated human TAK1 phosphorylates MKK3/MKK6 [Homo sapiens]
[Reaction:937075] Phosphorylated TAK1 leaves activated TLR receptor complex [Homo sapiens]
[Reaction:9757952] Activated TAK1 phosphorylates IKBKB [Homo sapiens]
(updatedInstance)[_UpdateTracker:9782070] Update Tracker - [Reaction:936951] Activation of TAK1 complex bound to activated TLR4 complex - v59:[modifyText]
[_UpdateTracker:9788197] Update Tracker - [Reaction:936951] Activation of TAK1 complex bound to activated TLR4 complex - v43:[modifyText]
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