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Details on Person Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2

Class:Id	BlackBoxEvent:936942
_displayName	Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2
_doRelease	TRUE
_timestamp	2012-11-19 21:55:01
authored	[InstanceEdit:847735] Shamovsky, V, 2010-06-01
catalystActivity	[CatalystActivity:936958] ubiquitin-protein transferase activity of p-IRAK2:oligo-TRAF6 [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:936971] Shamovsky, V, 2010-08-25
edited	[InstanceEdit:2562589] Shamovsky, V, 2012-11-06
input	[Complex:936990] p-IRAK2:oligo-TRAF6 [plasma membrane] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:202511] Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation
modified	[InstanceEdit:1018389] Shamovsky, V, 2010-11-16 [InstanceEdit:1094898] Shamovsky, V, 2010-11-29 [InstanceEdit:1095193] Shamovsky, V, 2010-11-30 [InstanceEdit:2603262] Shamovsky, V, 2012-11-19 [InstanceEdit:2627684] Shamovsky, V, 2012-11-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2
output	[Complex:936988] p-IRAK2:K63-linked pUb oligo-TRAF6 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:936963] IRAK2 induces TRAF6 oligomerization [Homo sapiens] [Reaction:166362] Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex [Homo sapiens] [Reaction:975879] Dissociation of hp-IRAK1:TRAF6 or IRAK2:TRAF6-oligomer from the activated TLR5 or 10:oligo-Myd88:p-IRAK4 complex [Homo sapiens]
releaseDate	2010-12-14
requiredInputComponent	[Complex:202463] UBE2N:UBE2V1 [cytosol] [Homo sapiens]
reviewed	[InstanceEdit:1095192] Gillespie, ME, 2010-11-30 [InstanceEdit:2603254] Napetschnig, Johanna, 2012-11-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104476] R-HSA-936942.2
summation	[Summation:202446] TRAF6 possesses ubiquitin ligase activity and undergoes K-63...
(hasEvent)	[Pathway:937042] IRAK2 mediated activation of TAK1 complex [Homo sapiens]
(precedingEvent)	[Reaction:936960] Activated TRAF6:p-IRAK2 interacts with TAK1 complex [Homo sapiens] [Polymerisation:936986] Activated TRAF6 synthesizes unanchored polyubiquitin chains [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9788225] Update Tracker - [BlackBoxEvent:936942] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 - v43:[modifyText] [_UpdateTracker:9789991] Update Tracker - [BlackBoxEvent:936942] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 - v36:[modifyText]
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