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Details on Person Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their activation

Class:IdReaction:936941
_displayNameRecruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their activation
_doReleaseFALSE
_timestamp2024-03-03 21:48:16
authored[InstanceEdit:847735] Shamovsky, V, 2010-06-01
compartment[Compartment:74700] endosome membrane
[Compartment:70101] cytosol
created[InstanceEdit:936971] Shamovsky, V, 2010-08-25
edited[InstanceEdit:5483109] Shamovsky, V, 2014-05-16
input[SimpleEntity:113592] ATP [cytosol]
[DefinedSet:450329] TBK1, IKBKE [cytosol] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
[DefinedSet:450329] TBK1, IKBKE [cytosol] [Homo sapiens]
[Complex:5362507] K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:165917] The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection
[LiteratureReference:166859] IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway
[LiteratureReference:202505] Regulation and function of IKK and IKK-related kinases
[LiteratureReference:5362581] Crystal structure and mechanism of activation of TANK-binding kinase 1
modified[InstanceEdit:1018390] Shamovsky, V, 2010-11-16
[InstanceEdit:1094899] Shamovsky, V, 2010-11-29
[InstanceEdit:1095195] Shamovsky, V, 2010-11-30
[InstanceEdit:1095198] Shamovsky, V, 2010-11-30
[InstanceEdit:1564971] Shamovsky, V, 2011-09-06
[InstanceEdit:1602499] Shamovsky, V, 2011-09-14
[InstanceEdit:2201355] Shamovsky, V, 2012-04-19
[InstanceEdit:2206363] Shamovsky, V, 2012-04-26
[InstanceEdit:2213022] Shamovsky, V, 2012-04-27
[InstanceEdit:2248861] Shamovsky, V, 2012-05-15
[InstanceEdit:2299706] Shamovsky, V, 2012-06-01
[InstanceEdit:2582979] Shamovsky, V, 2012-11-13
[InstanceEdit:2632486] Shamovsky, V, 2012-11-20
[InstanceEdit:2632490] Shamovsky, V, 2012-11-20
[InstanceEdit:5362483] Shamovsky, V, 2014-04-16
[InstanceEdit:5362622] Shamovsky, V, 2014-04-16
[InstanceEdit:5483109] Shamovsky, V, 2014-05-16
[InstanceEdit:5492218] Shamovsky, V, 2014-05-20
[InstanceEdit:9013860] Shamovsky, Veronica, 2017-07-26
[InstanceEdit:9823885] Shamovsky, Veronica, 2023-01-11
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9863564] Shamovsky, Veronica, 2024-03-03
nameRecruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their activation
output[DefinedSet:936970] activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
releaseDate2010-12-14
reviewed[InstanceEdit:1095192] Gillespie, ME, 2010-11-30
[InstanceEdit:2582977] Fitzgerald, Katherine A, 2012-11-13
[InstanceEdit:5483106] Masci, Anna Maria, 2014-05-16
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1104691] R-HSA-936941.4
summation[Summation:433959] Upon stimulation by pathogen-associated inflammatory signals...
(replacementInstances)[_Deleted:3371608] Deletion of instance: 168926
(updatedInstance)[_UpdateTracker:9786633] Update Tracker - [Reaction:936941] Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their phosphorylation - v49:[addLiteratureReference, add_removeInput, modifyText]
[_UpdateTracker:9788131] Update Tracker - [Reaction:936941] Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their phosphorylation - v43:[modifyText]
[_UpdateTracker:9788682] Update Tracker - [Reaction:936941] Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their phosphorylation - v41:[add_removeInput]
[_UpdateTracker:9789721] Update Tracker - [Reaction:936941] Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their phosphorylation - v37:[modifyText]
[_UpdateTracker:9846795] Update Tracker - [Reaction:936941] Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their activation - v84:[modifyText]
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