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Details on Person ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+

Class:IdReaction:936897
_displayNameATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+
_doReleaseTRUE
_timestamp2020-06-01 08:21:06
authored[InstanceEdit:936867] Jassal, Bijay, 2010-08-24
catalystActivity[CatalystActivity:936847] P-type sodium:potassium-exchanging transporter activity of ATP1A:ATP1B:FXYD [plasma membrane]
compartment[Compartment:876] plasma membrane
created[InstanceEdit:936867] Jassal, Bijay, 2010-08-24
edited[InstanceEdit:936867] Jassal, Bijay, 2010-08-24
input[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:29356] H2O [cytosol]
[SimpleEntity:83910] Na+ [cytosol]
[SimpleEntity:74126] K+ [extracellular region]
[SimpleEntity:83910] Na+ [cytosol]
[SimpleEntity:83910] Na+ [cytosol]
[SimpleEntity:74126] K+ [extracellular region]
isChimericFALSE
literatureReference[LiteratureReference:936834] Primary structure of the alpha-subunit of human Na,K-ATPase deduced from cDNA sequence
[LiteratureReference:936790] Characterization of the human Na,K-ATPase alpha 2 gene and identification of intragenic restriction fragment length polymorphisms
[LiteratureReference:936778] Family of human Na+, K+-ATPase genes. Structure of the gene for the catalytic subunit (alpha III-form) and its relationship with structural features of the protein
[LiteratureReference:936759] Physical mapping and characterization of the human Na,K-ATPase isoform, ATP1A4
[LiteratureReference:936882] Characterization of two genes for the human Na,K-ATPase beta subunit
[LiteratureReference:936879] Expression and synthesis of the Na,K-ATPase beta 2 subunit in human retinal pigment epithelium
[LiteratureReference:936846] Identification of the mammalian Na,K-ATPase 3 subunit
[LiteratureReference:936902] Dominant isolated renal magnesium loss is caused by misrouting of the Na(+),K(+)-ATPase gamma-subunit
[LiteratureReference:936833] Alternating hemiplegia of childhood or familial hemiplegic migraine? A novel ATP1A2 mutation
[LiteratureReference:936849] Novel mutations in the Na+, K+-ATPase pump gene ATP1A2 associated with familial hemiplegic migraine and benign familial infantile convulsions
[LiteratureReference:936798] Mutations in the Na+/K+ -ATPase alpha3 gene ATP1A3 are associated with rapid-onset dystonia parkinsonism
[LiteratureReference:2752101] A genetic association study of chromosome 11q22-24 in two different samples implicates the FXYD6 gene, encoding phosphohippolin, in susceptibility to schizophrenia
modified[InstanceEdit:984582] Jassal, Bijay, 2010-11-02
[InstanceEdit:1014331] Jassal, Bijay, 2010-11-15
[InstanceEdit:2752102] Jassal, Bijay, 2012-12-07
[InstanceEdit:2867914] Jassal, Bijay, 2012-12-19
[InstanceEdit:9670545] Jassal, Bijay, 2019-12-10
[InstanceEdit:9690290] Jassal, Bijay, 2020-05-29
[InstanceEdit:9690425] Jassal, Bijay, 2020-06-01
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+
The Na+/K+-transporting ATPase trimer exchanges sodium for potassium
output[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29804] K+ [cytosol]
[SimpleEntity:29372] Pi [cytosol]
[SimpleEntity:74113] Na+ [extracellular region]
[SimpleEntity:29804] K+ [cytosol]
[SimpleEntity:74113] Na+ [extracellular region]
[SimpleEntity:74113] Na+ [extracellular region]
regulatedBy[NegativeRegulation:9690307] Negative regulation by 'ATP1A:ATP1B:FXYD:cardiac glycosides [plasma membrane]'
releaseDate2010-12-14
reviewed[InstanceEdit:1014332] He, Lei, 2010-11-15
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:2752085] Jassal, Bijay, 2012-12-07
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1105486] R-HSA-936897.4
summation[Summation:936822] The sodium/potassium-transporting ATPase (ATP1A:ATP1B:FXYD) ...
(hasEvent)[Pathway:936837] Ion transport by P-type ATPases [Homo sapiens]
[Pathway:5578775] Ion homeostasis [Homo sapiens]
[Pathway:9670176] AP - hyperpolarization [Homo sapiens]
[Pathway:9670455] AP - resting membrane potential [Homo sapiens]
(updatedInstance)[_UpdateTracker:9776735] Update Tracker - [Reaction:936897] ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ - v74:[addRegulator]
[_UpdateTracker:9783841] Update Tracker - [Reaction:936897] ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ - v55:[modifyText]
[_UpdateTracker:9787754] Update Tracker - [Reaction:936897] ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ - v44:[add_removeLiteratureReference, modifyText]
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