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Details on Person ATP7A transports cytosolic Cu1+ to extracellular region

Class:IdReaction:936802
_displayNameATP7A transports cytosolic Cu1+ to extracellular region
_doReleaseTRUE
_timestamp2025-11-07 17:19:09
authored[InstanceEdit:936867] Jassal, Bijay, 2010-08-24
catalystActivity[CatalystActivity:936821] P-type monovalent copper transporter activity of ATP7A:PDZD11 [plasma membrane]
compartment[Compartment:876] plasma membrane
created[InstanceEdit:936867] Jassal, Bijay, 2010-08-24
crossReference[DatabaseIdentifier:9970125] RHEA:25794
edited[InstanceEdit:936867] Jassal, Bijay, 2010-08-24
input[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:29356] H2O [cytosol]
[SimpleEntity:3299744] Cu1+ [cytosol]
internalReviewed[InstanceEdit:9971584] D'Eustachio, Peter, 2025-11-07
isChimericFALSE
literatureReference[LiteratureReference:936777] Isolation of a candidate gene for Menkes disease and evidence that it encodes a copper-transporting ATPase
[LiteratureReference:936757] Isolation of a candidate gene for Menkes disease that encodes a potential heavy metal binding protein
[LiteratureReference:936768] Immunocytochemical localization of the Menkes copper transport protein (ATP7A) to the trans-Golgi network
[LiteratureReference:936886] The Menkes protein (ATP7A; MNK) cycles via the plasma membrane both in basal and elevated extracellular copper using a C-terminal di-leucine endocytic signal
[LiteratureReference:936865] Defective copper-induced trafficking and localization of the Menkes protein in patients with mild and copper-treated classical Menkes disease
modified[InstanceEdit:984582] Jassal, Bijay, 2010-11-02
[InstanceEdit:1014331] Jassal, Bijay, 2010-11-15
[InstanceEdit:2867914] Jassal, Bijay, 2012-12-19
[InstanceEdit:5362694] Jassal, Bijay, 2014-04-17
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9970139] Stephan, Ralf, 2025-10-28
[InstanceEdit:9971587] D'Eustachio, Peter, 2025-11-07
[InstanceEdit:9971589] D'Eustachio, Peter, 2025-11-07
nameATP7A transports cytosolic Cu1+ to extracellular region
Copper export from cells by copper-transporting ATPase1
output[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29372] Pi [cytosol]
[SimpleEntity:70106] H+ [cytosol]
[SimpleEntity:9970133] Cu1+ [extracellular region]
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2010-12-14
reviewed[InstanceEdit:1014332] He, Lei, 2010-11-15
[InstanceEdit:9971588] D'Eustachio, Peter, 2025-11-07
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:5358999] Jassal, Bijay, 2014-04-07
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1104648] R-HSA-936802.3
structureModified[InstanceEdit:9970139] Stephan, Ralf, 2025-10-28
summation[Summation:936764] The human gene ATP7A (MNK) encodes the copper-transporting A...
(hasEvent)[Pathway:936837] Ion transport by P-type ATPases [Homo sapiens]
(precedingEvent)[BlackBoxEvent:5358976] ATP7A:PDZD11 translocates from plasma membrane to TGN membrane
(updatedInstance)[_UpdateTracker:9787541] Update Tracker - [Reaction:936802] ATP7A transports cytosolic Cu2+ to extracellular region - v44:[modifyText]
[_UpdateTracker:9971923] Update Tracker - [Reaction:936802] ATP7A transports cytosolic Cu1+ to extracellular region - v95:[add_removeInput, add_removeOutput]
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