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Details on Person Negative regulation of DDX58/IFIH1 signaling by RNF216

Class:Id	BlackBoxEvent:936475
_displayName	Negative regulation of DDX58/IFIH1 signaling by RNF216
_doRelease	TRUE
_timestamp	2023-05-18 14:07:50
authored	[InstanceEdit:918228] Garapati, P V, 2010-08-02
catalystActivity	[CatalystActivity:936474] ubiquitin protein ligase activity of RNF216 [cytosol]
catalystActivityReference	[CatalystActivityReference:9644064] ubiquitin protein ligase activity of RNF216 [cytosol] The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation
compartment	[Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:936473] Garapati, P V, 2010-08-22
edited	[InstanceEdit:936473] Garapati, P V, 2010-08-22
input	[Complex:936558] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:TRAF3 [mitochondrial outer membrane] [Homo sapiens] [Polymer:912740] K48polyUb [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:936472] The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation
modified	[InstanceEdit:936565] Garapati, P V, 2010-08-23 [InstanceEdit:990524] Garapati, P V, 2010-11-03 [InstanceEdit:994081] Garapati, P V, 2010-11-05 [InstanceEdit:998145] Garapati, P V, 2010-11-09 [InstanceEdit:1097350] Jassal, B, 2010-11-30 [InstanceEdit:6791276] Garapati, Phani Vijay, 2015-08-20 [InstanceEdit:8983918] Jupe, Steve, 2017-03-31 [InstanceEdit:9014715] Shamovsky, Veronica, 2017-08-02 [InstanceEdit:9031715] D'Eustachio, Peter, 2017-12-01 [InstanceEdit:9031726] D'Eustachio, Peter, 2017-12-01 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9835836] Shamovsky, Veronica, 2023-05-18
name	Negative regulation of DDX58/IFIH1 signaling by RNF216 Negative regulation of RIG-I/MDA5 signaling by TRIAD3A
output	[Complex:918201] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] [Homo sapiens] [EntityWithAccessionedSequence:936556] K48polyUb-TRAF3 [cytosol] [Homo sapiens]
relatedSpecies	[Species:5621375] Hepatitis C Virus [Species:9013948] Measles virus [Species:5617433] Rotavirus [Species:9031716] Influenza A virus [Species:9717528] Human respiratory syncytial virus A
releaseDate	2010-12-14
reviewed	[InstanceEdit:990527] Kawai, T, Akira, S, 2010-10-30
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104272] R-HSA-936475.7
summation	[Summation:936532] TRAF3 is dual regulated by DUBA (OTUD5) and TRIAD3A (RNF216)...
(hasEvent)	[Pathway:936440] Negative regulators of DDX58/IFIH1 signaling [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9779620] Update Tracker - [BlackBoxEvent:936475] Negative regulation of DDX58/IFIH1 signaling by RNF216 - v65:[modifyText] [_UpdateTracker:9784093] Update Tracker - [BlackBoxEvent:936475] Negative regulation of DDX58/IFIH1 signaling by RNF216 - v54:[addCatalystActivity]
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