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Details on Person RNF125 acts as an E3-ubiquitin ligase that conjugates with R...
| Class:Id | Summation:936447 |
|---|---|
| _displayName | RNF125 acts as an E3-ubiquitin ligase that conjugates with R... |
| _timestamp | 2021-12-01 05:57:17 |
| created | [InstanceEdit:936409] Garapati, P V, 2010-08-22 |
| literatureReference | [LiteratureReference:936414] Negative regulation of cytoplasmic RNA-mediated antiviral signaling [LiteratureReference:936460] Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125 |
| modified | [InstanceEdit:9759225] Shamovsky, Veronica, 2021-12-01 |
| text | RNF125 acts as an E3-ubiquitin ligase that conjugates with RIG-I (DDX58), MDA5 (IFIH1) and IPS-1 (MAVS) and mediate their proteosomal degradation. UbcH1, UbcH5a, UbcH5b, and UbcH5c function as an E2 enzyme and conjugate ubiquitin to RNF125 and DDX58 via K48. Among these enzymes UbcH5c is the major E2 enzyme showing enhanced ubiquitin conjugation to DDX58. RNF125 mediated ubiquitination of RIG-I, MDA5 and MAVS (IPS-1) inhibits DDX58/IFIH1 signaling by shunting these proteins toward proteasomal degradation. |
| (summation) | [BlackBoxEvent:936401] RNF125 mediated ubiquitination of RIG-I, MDA5 and IPS-1 [Mus musculus] [BlackBoxEvent:936412] RNF125 mediated ubiquitination of DDX58, IFIH1 and MAVS [Homo sapiens] |
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No pathways have been reviewed or authored by RNF125 acts as an E3-ubiquitin ligase that conjugates with R... (936447)
