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Details on Person RNF125 mediated ubiquitination of RIG-I, MDA5 and IPS-1

Class:Id	BlackBoxEvent:936401
_displayName	RNF125 mediated ubiquitination of RIG-I, MDA5 and IPS-1
_doRelease	TRUE
_timestamp	2010-12-02 14:37:33
authored	[InstanceEdit:936409] Garapati, P V, 2010-08-22
catalystActivity	[CatalystActivity:936404] ubiquitin-protein transferase activity of Rnf125:E2 enzyme (UBE2K, UbcH5a-c):K48-polyubiquitin [cytosol]
catalystActivityReference	[CatalystActivityReference:9643937] ubiquitin-protein transferase activity of Rnf125:E2 enzyme (UBE2K, UbcH5a-c):K48-polyubiquitin [cytosol] Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:936409] Garapati, P V, 2010-08-22
edited	[InstanceEdit:936409] Garapati, P V, 2010-08-22
input	[DefinedSet:936436] DDX58, IFIH1 [cytosol] [Homo sapiens]
isChimeric	TRUE
literatureReference	[LiteratureReference:936460] Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125
modified	[InstanceEdit:990524] Garapati, P V, 2010-11-03 [InstanceEdit:994081] Garapati, P V, 2010-11-05 [InstanceEdit:998145] Garapati, P V, 2010-11-09 [InstanceEdit:1097351] Jassal, B, 2010-11-30 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RNF125 mediated ubiquitination of RIG-I, MDA5 and IPS-1
output	[CandidateSet:936441] E2 enzyme (UBE2K, UbcH5a-c) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:936457] Rnf125 [cytosol] [Mus musculus] [DefinedSet:983460] K48polyUb-DDX58,K48polyUb-IFIH1 [cytosol] [Homo sapiens]
releaseDate	2010-12-14
reviewed	[InstanceEdit:990527] Kawai, T, Akira, S, 2010-10-30
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus [Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105068] R-NUL-936401.3
summation	[Summation:936447] RNF125 acts as an E3-ubiquitin ligase that conjugates with R...
(inferredFrom)	[BlackBoxEvent:936412] RNF125 mediated ubiquitination of DDX58, IFIH1 and MAVS [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9774857] Update Tracker - [BlackBoxEvent:936401] RNF125 mediated ubiquitination of RIG-I, MDA5 and IPS-1 - v80:[modifyText]
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No pathways have been reviewed or authored by RNF125 mediated ubiquitination of RIG-I, MDA5 and IPS-1 (936401)