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Details on Person DRK:DOS complex binds to phosphorylated CSW

Class:Id	Reaction:936027
_displayName	DRK:DOS complex binds to phosphorylated CSW
_doRelease	FALSE
_timestamp	2017-06-27 17:35:30
authored	[InstanceEdit:936025] Williams, MG, 2010-08-19
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:936017] Williams, MG, 2010-08-19
input	[Complex:443299] C-TRK:Phospho (6 sites) TOR dimer:Phospho CSW [plasma membrane] [Drosophila melanogaster] [Complex:206791] DRK:DOS [cytosol] [Drosophila melanogaster]
isChimeric	FALSE
literatureReference	[LiteratureReference:443086] Opposing actions of CSW and RasGAP modulate the strength of Torso RTK signaling in the Drosophila terminal pathway [LiteratureReference:936026] DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between sevenless and Ras1 in Drosophila [LiteratureReference:379168] The Drosophila SHC adaptor protein is required for signaling by a subset of receptor tyrosine kinases
modified	[InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9010639] D'Eustachio, Peter, 2017-06-27
name	DRK:DOS complex binds to phosphorylated CSW
output	[Complex:936020] C-TRK:Phospho (6 sites) TOR dimer:Phospho CSW:DRK:DOS [plasma membrane] [Drosophila melanogaster]
precedingEvent	[Reaction:209265] DOS binds to DRK [Drosophila melanogaster] [Reaction:443170] Phosphorylated TOR phosphorylates CSW [Drosophila melanogaster] [Reaction:443180] CSW binds to phosphorylated TOR receptor [Drosophila melanogaster]
species	[Species:56210] Drosophila melanogaster
stableIdentifier	[StableIdentifier:8925594] R-DME-936027.1
summation	[Summation:936019] Torso (TOR) receptor tyrosine kinase lacks a consensus downs...
(hasEvent)	[Pathway:936024] Formation of DOS complex [Drosophila melanogaster]
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