Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:P15066 Jund
| Class:Id | ReferenceGeneProduct:93535 |
|---|---|
| _chainChangeLog | chain:1-341 added on Fri February 6 2015 |
| _displayName | UniProt:P15066 Jund |
| _timestamp | 2023-11-03 15:28:33 |
| chain | chain:1-341 |
| checksum | 2727392F6B65188D |
| comment | FUNCTION Transcription factor binding AP-1 sites (By similarity). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription factor complex, thereby enhancing its DNA binding activity to an AP-1 consensus sequence 3'-TGA[GC]TCA-5' and enhancing its transcriptional activity (By similarity).SUBUNIT Heterodimer; binds DNA as a heterodimer (By similarity). Component of an AP-1 transcription factor complex composed of JUN-FOS heterodimers (By similarity). As part of the AP-1 transcription factor complex, forms heterodimers with FOS proteins, thereby binding to the AP-1 consensus sequence and stimulating transcription (By similarity). Forms heterodimers with FOSB; thereby binding to the AP-1 consensus sequence (By similarity). Interacts (via MBM motif) with MEN1; this interaction represses transcriptional activation (PubMed:9989505). Interacts with MAPK10; this interaction is inhibited in the presence of MEN1 (By similarity).SUBCELLULAR LOCATION Brain and kidney.DOMAIN Binds DNA via bZIP domain; DNA-binding is under control of cellular redox homeostasis (in vitro) (By similarity). To enable DNA binding, the bZIP domain must undergo a conformational rearrangement which requires the reduction of the interchain disulfide bond between FosB and JunD (in vitro) (By similarity).PTM Phosphorylated by MAP kinases MAPK8 and MAPK10; phosphorylation is inhibited in the presence of MEN1.SIMILARITY Belongs to the bZIP family. Jun subfamily. |
| description | recommendedName: fullName evidence="7"Transcription factor JunD alternativeName: fullName evidence="7"Transcription factor AP-1 subunit JunD |
| geneName | Jund Jun-d Jund1 |
| identifier | P15066 |
| isSequenceChanged | FALSE |
| keyword | Disulfide bond DNA-binding Nucleus Phosphoprotein Reference proteome Transcription Transcription regulation |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2587579] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9773244] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Jund |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | JUND_MOUSE |
| sequenceLength | 341 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:9967165] Jund [nucleoplasm] [Mus musculus] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P15066 Jund (93535)
